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Date Published: 28/02/2024
Abstract Views: 59
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DOI: https://doi.org/10.56535/jmpm.v49i2.605
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Vol. 49 No. 2 (2024): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 2 - 2024
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Articles
How to Cite
Hoàng, T. T. T., Dương, H. O., Hồ, S. H., & Trinh, T. S. (2024). HVQY75-Comparison of pregnancy rate after frozen embryo transfer between two group oocyte trigger by GnRH agonist versus hCG. Journal of Military Pharmaco-medicine, 49(2), 88-96. https://doi.org/10.56535/jmpm.v49i2.605

HVQY75-Comparison of pregnancy rate after frozen embryo transfer between two group oocyte trigger by GnRH agonist versus hCG

Thị Thanh Thuỷ Hoàng, Hồng Oanh Dương, Sỹ Hùng Hồ, Trinh The Son1,
1 Military Hospital 103

Main Article Content

Abstract

Comparison of pregnancy rate after frozen embryo transfer


 between two group oocyte trigger by GnRH agonist versus hCG


                           Hoang Thi Thanh Thuy 1,Dương Hong Oanh 2,Ho Sy Hung1, Trinh The Son3


1Ha noi Medical University, 2Đong Anh General Hospital, 3Military Institute of Clinical Embryology and Histology, Vietnam Military Medical University


 


 


A retrospective cohort study that analyzed 219 cryopreserved embryo transfer cycles at the National Reproductive Center from January 1, 2020 to December 31, 2020. Objective: compare the pregnancy rate of frozen embryo transfer between two groups oocyte trigger by GnRH agonist versus hCG. Result(s): The main causes of infertility in both groups were ovulation disorders and tubal problems: 79/110 (71.8%), 12/110 (13.6%) in the GnRHa group and 68/109(62.3%), 21/109(19.3%) in the hCG group The mean AMH concentration in the GnRH agonist group was higher than in the hCG group (7.3 ±  4.6 ng/ml vs 4.2 ± 2.1 ng/ml). The mean number of secondary follicles in the GnRHa group (25.8 ± 9.9 follicles) was higher than that in the hCG group (18.1 ± 8.5 follicles) The average first dose of FSH: 188.4 ± 44.4 UI (GnRH group) was lower than 226.4 ± 51.5 UI (hCG group). Patients in the GnRHa group had a higher number of oocytes obtained than in the hCG group (22.9 ± 8.8 oocytes versus 16.8 ± 5.8 oocytes); the mean number of MII mature oocytes was higher (17.5 ± 8.4 oocytes vs 13.5 ± 5.0); the average number of embryos was higher (9.3 ± 5.3 embryos compared with the hCG group was 6.2 ± 3.7 embryos). However, the proportion of mature MII oocytes was similar (77.3% in the GnRHa group vs 81.5% in the hCG group) and the fertilization rate was similar (72.2% in the GnRHa group versus 74.7% in the hCG group). The pregnancy outcomes of the two groups inducing oocyte maturation by GnRHa and hCG were similar: pregnancy rate (63.7% vs 54.1%), clinical pregnancy rate (50.1 vs 45%) ) and ongoing pregnancy rate (44.5 vs 39.4).


Conclusion(s):Oocyte maturation with GnRHagonist had no effect on pregnancy rates after frozen embryo transfer cycles. Pregnancy rates after frozen embryo transfer in the oocyte maturation group with GnRH agonists and hCG were similar.


Keywords: oocyte maturation, GnRH agonist, hCG, cryopreserved embryo transfer.

Article Details

Keywords

oocyte maturation, GnRH agonist, hCG, cryopreserved embryo transfer.

References

1. Youssef MA, Van der Veen F, Al-Inany HG, et al. Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering inantagonist assisted reproductive technology cycles. Cochrane DatabaseSyst Rev. 2011; 1.
2. Atkinson P, Koch J, Ledger WL. Gn RH agonist trigger and a freeze-allstrategy to prevent ovarian hyperstimulation syndrome: A retrospectivestudy of OHSS risk and pregnancy rates. Aust N Z J Obstet Gynaecol. 2014; 54(6):581-585.
3. Borges Jr E, Braga DP, Setti AS, et al. Strategies for the management of OHSS: Results from freezing-all cycles. JBRA Assist Reprod. 2016; 20(1):8-12.
4. Kaye L, Marsidi A, Rai P, et al. Frozen blastocyst transfer outcomes inimmediate versus delayed subsequent cycles following GnRH agonist orhCG triggers. J Assist Reprod Genet. 2018; 35(4):669-675.
5. Vương Thị Ngọc Lan, Giang Huỳnh Như. Sử dụng GnRH đồng vận thay thế hCG trong khởi động trưởng thành noãn ở chu kỳ kích thích buồng trứng bằng phác đồ GnRH đối vận. Tạp chí Y Học TP Hồ Chí Minh. 2012; 16(1):175-179.
6. La Thị Phương Thảo. So sánh hiệu quả phòng ngừa hội chứng quá kích buồng trứng và chất lượng noãn của phác đồ gây trưởng thành noãn bằng GnRH agonist và hCG. Luận văn thạc sĩ y học. Đại học Y Hà Nội. 2017.
7. Helle Ejdrup Bredkjær, Peter Humaidan, Lars Grabow W, et al. 1,500 IU human chorionic gonadotropin administered at oocyte retrievalrescues the luteal phase when gonadotropin-releasing hormone agonist isused for ovulation induction: A prospective, randomized, controlledstudy. Fertility and Sterility. 2010; 93(3):847-854.
8. Fauser BC, De Jong D, Olivennes F, et al. Endocrine profiles aftertriggering of final oocyte maturation with GnRH agonist aftercotreatment with the GnRH antagonist ganirelix during ovarianhyperstimulation for in vitro fertilization. J Clin Endocrinol Metab. 2002; 87(2):709-715.