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Date Published: 28/02/2024
Abstract Views: 76
Views PDF: 64
DOI: https://doi.org/10.56535/jmpm.v49i2.597
Issue
Vol. 49 No. 2 (2024): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 2 - 2024
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Articles
How to Cite
Phan, T. T. N., Hoang, T. V., Vu, B. Q., & Pham, T. T. (2024). CHANGES IN SERUM ADIPONECTIN LEVELS IN WOMEN WITH GESTA-TIONAL DIABETES MELLITUS DURING MILD- AND LATE PREGNANCY. Journal of Military Pharmaco-medicine, 49(2), 205-216. https://doi.org/10.56535/jmpm.v49i2.597

CHANGES IN SERUM ADIPONECTIN LEVELS IN WOMEN WITH GESTA-TIONAL DIABETES MELLITUS DURING MILD- AND LATE PREGNANCY

Thi To Nhu Phan1, , Trung Vinh Hoang2, Ba Quyet Vu3, The Tai Pham4
1 Dai hoc Duoc Ha Noi
2 Military Hospital 103, Vietnam Military Medical University
3 National Hospital of Obstetrics and Gynecology
4 Institute of Biomedicine and Pharmacy, Vietnam Military Medical University

Main Article Content

Abstract

Objectives: To observe the changes in serum adiponectin levels in women with gestational diabetes mellitus (GDM) during mild- and late pregnancy. Methods: A case-control study, with longitudinal follow up on 120 GDM cases and 120 controls at 24-28 weeks of gestational. Results: Serum adiponectin levels in pregnant women gradually decreased as pregnancy progressed. In mid- and late pregnancy, women with GDM had lower serum adiponectin levels than normal pregnant women (2.79 (2.13 - 4.57) vs. 4.26 (3.4 - 7.2) mg/L; P < 0.001 and 2.01 (1.2 - 3.03) vs 3.05 (2.26 - 5.48) mg/L; P < 0.001). Serum adiponectin levels in mid- and late pregnancy were negatively correlated with pre-pregnancy BMI (r = -0.712; P < 0.001 and r = -0.679; P < 0.001); serum insulin levels (r = -0.643; P < 0.001 and r = -0.581; P < 0.001) and HOMA-IR index (r = -0.661; P < 0.001 and r = -0.582; P < 0.001). Conclusion: Serum adiponectin levels was lower in GDM and had a negative correlation with insulin resistance. Low adiponectin levels may be a risk factor for GDM in pregnant women.

Article Details

Keywords

Gesational diabetes mellitus, adiponectin, insulin resistance, adipokines

References

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