NGHIÊN CỨU GIÁ TRỊ NLR, PLR VÀ MỘT SỐ CHỈ SỐ HÓA SINH MÁU Ở BỆNH NHÂN U LYMPHO ÁC TÍNH KHÔNG HODGKIN TẠI BỆNH VIỆN QUÂN Y 103

Abstract

Objectives: determine the optimal value threshold of NLR (Neutrophile to Lymphocyte Ratio), PLR (Platelet to Lymphocyte Ratio) in prognosis, treatment response of malignant non-Hodgkin lymphoma and the relationship with some clinical factors. Methods: 31 patients with malignant non-Hodgkin lymphoma were treated at Department A7 - Military Hospital 103, from January to December 2022 and 31 healthy people were examined and tested at the clinic which are similarities in age and gender at the clinic; determine the values of NLR, PLR and some blood biochemical indices. Results: average age is 60 years old, male (67.74%). Weight loss (29.03%), and night sweats (16.13%) are the two most common systemic symptoms, Performance Status (PS) index 0-2, mainly PS 0-1 (90.32%). Patients with enlarged lymph nodes (80.65%), and a single group of lymph nodes (45.16%). Immunohistochemistry: CD20 (+) (91.30%). The optimal value thresholds of NLR and PLR indexes in disease prognosis are 1.85 and 127.3; this is related to the Performance Status index and the number of lymph node groups. Conclusion: patients with malignant non-Hodgkin lymphoma at Department A7 - Military Hospital 103 (average age: 60, male (67%), performance status index score mainly PS 0-1; the majority of patients have one group lymph nodes, common systemic symptoms (weight loss and night sweats). The optimal threshold values of the NLR and PLR index in disease prognosis are 1.85 and 127.3. NLR and PLR have a relationship statistically significant for some systemic symptoms, performance status index and number of lymph node groups.

*Keywords: malignant lymphoma;NLR; PLR.