PHÂN TÍCH ĐẶC ĐIỂM TRIỆU CHỨNG NGOÀI VẬN ĐỘNG Ở BỆNH NHÂN PARKINSON KHỞI PHÁT SỚM

Abstract

Objectives: To analyze the characteristics of non-motor symptoms and determine the correlation of these symptoms with some other factors of early-onsetParkinson’s disease (EOPD). Methods: A prospective cross-sectional descriptive study analysing 135 early-onset Parkinson's patients from April 2019 to December 2021. General information of patients was collected according to the constant medical record. Non-motor symptoms were scored according to the Non-Motor Symptoms Scale (NMSS). Results: Symptomatic group “Sleep/fatigue”, “Mood/Cognition”, “Attention/memory”, “Miscellaneous”; “Cardiovascular”, “Gastrointestinal tract”, “Urinary”, “Sexual function”; “Perception/hallucination” accounted for 91.1%; 86.7%; 81.5%; 68.1%; 65.9%; 57%; 57%; 51.9% and 15.6%, respectively. Non-motor symptoms (NMSS score) were positively correlated with age of disease onset (r = 0.359), disease duration (r = 0.304), disease severity (UPDRS score, r = 0.470), disease stage (HY score, r = 0.267), pain (KPPS score, r = 0.679), depression (BECK score, r = 0.597) and cognitive status (MMSE score, r = -0.589). Conclusion: Non-motor symptoms are very common (91.1% of patients have at least one symptom). The groups of symptoms that are more common and severe are “Sleep/fatigue”: 91.1%; “Mood/Cognition”: 86.7%, “Attention/memory”: 81.5%, and “Cardiovascular”: 65.9%. Non-motor symptoms correlated with age, disease severity, disease stage, pain, depression, and cognitive impairment.