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PREPARATION OF FAMOTIDINE-LOADED SOLID LIPID NANOPARTICLES
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Abstract
Objectives: To prepare and evaluate some properties of famotidine-loaded solid lipid nanoparticles. Methods: Solid lipid nanoparticles were prepared by high-shear homogenization combined with ultrasonication. The formulations of FTD-loaded lipid nanoparticles were evaluated for some properties using physico-chemical methods. Results: Factors belonging to the formula composition (solid lipids, surfactants, extra-phase solvents) and process parameters (speed, time, and speed of homogenization, power, and time of sonication) were evaluated to find the optimal process. The FTD-load nanoparticle formula was selected, including 40mg famotidine, 3.5g GMS, 1g Span 80, 300mL of water containing 0.75g Tween 80; process parameters were: Homogenization speed 7000 r.p.m, homogenization time 5 minutes, sonication power 240W, sonication time 5 minutes. The solid lipid nanosystem has a droplet size of 124.9 ± 0.19nm, PDI < 0.3. Profile of FTD-load solid lipid nanoparticles showed the capability of extending drug release up to 12 hours. Conclusion: The formulation, process parameters, and evaluation of some properties of solid lipid nanosystems containing famotidine have been developed.
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Keywords
Famotidine, Solid lipid nanoparticles, Homogenization, Glycerol monosterate
References
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