ẢNH HƯỞNG CỦA TÁ DƯỢC ĐẾN BÀO CHẾ BỘT CAO KHÔ DIỆP HẠ CHÂU ĐẮNG BẰNG PHƯƠNG PHÁP PHUN SẤY

Abstract

Objectives: To investigate the effects of excipients on the preparation of Phyllanthus  amarus  Schum.  et  Thonn.  dry  extract  powder  by  spray-drying. Methods: Phyllanthus amarus Schum. et Thonn. extract (5:1) was spray-dried by LPG-5 with different excipients and excipient/residue ratios. Evaluating the humidity, hygroscopicity, tap density, Carr's compressibility index, spray drying yield, phyllanthine (PHY) content and recovery of products. Results: Excipients improved the performance and quality of Phyllanthus amarus dry extract powder prepared by spray drying. The combination of excipients has improved the tap density. Increasing the excipient ratio increases spray drying efficiency but reduces the active ingredient content. The most suitable excipient to prepare Phyllanthus amarus dry extract powder was Aerosil/polyvinyl pyrrolidone K30 (1:1, kl/kl) with an excipients/ residue ratio of 20%. The dry extract powder has moisture < 5%, phyllanthin content of 9.05 ± 0.07 mg/g, density of 0.73 ± 0.01 g/mL, and spray drying efficiency of 64.47%. Conclusion: The suitable excipient to prepare Phyllanthus amarus dry extract powder by spray drying method is Aerosil/polyvinyl pyrrolidone K30 (1:1) with an excipients/ residue ratio of 20%.