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SCREENING AND EVALUATION OF ANTIDIABETIC ACTIVITY OF SEVERAL MEDICINAL PLANTS IN VIETNAM
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Abstract
Objectives: To screen the protein tyrosine phosphatase 1B (PTP1B) enzyme inhibitory activity of six medicinal plants in Vietnam and evaluate the glucose-lowering effect in vivo of the medicinal plant extract with the best enzyme inhibitory activity. Methods: Medicinal plants were extracted with ethanol 70% and were evaluated for their PTP1B enzyme inhibitory effect in vitro. The in vivo experiment was performed in a streptozocin-induced diabetic mice model. Results: The extract from the aerial parts of Commelina diffusa showed the highest PTP1B enzyme inhibition with an IC50 value of 8.34 ± 2.36 µg/mL compared to positive control (ursolic acid, IC50 = 0.52 ± 0.04 µg/mL). This extract at doses of 500 mg/kg and 1000 mg/kg significantly reduced blood glucose levels and did not affect the weight and lipid profile of experimental mice. Conclusion: There is a high potential for developing products supporting diabetes treatment from the extract of Commelina diffusa.
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Keywords
Hypoglycemic, Type 2 diabetes, Commelina diffusa, PTP1B
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