ĐÁNH GIÁ TÁC DỤNG ĐIỀU CHỈNH RỐI LOẠN LIPID MÁU NGOẠI SINH CỦA VIÊN NANG BÀO CHẾ TỪ TỎI ĐEN, BỤP GIẤM, TRẠCH TẢ VÀ GIẢO CỔ LAM TRÊN CHUỘT CỐNG TRẮNG

Abstract

Objectives: To evaluate the adjusting effects of external dyslipidemia of capsules prepared from Black Garlic, Hibiscus sabdariffa L., Alisma plantago-aquatica L., and Gynostemma pentaphyllum in white rats. Methods: According to the model of Nassiri et al. (2009), Wistar white rats were induced lipid disorders with cholesterol oil (10 mL/kg/24h dose). A total of 50 rats were assigned to 5 groups: Group 1 drank distilled water 10 mL/kg; Group 2 drank cholesterol oil + distilled water 10 mL/kg after 02 hours; Group 3 drank cholesterol oil + reagent dose 336 mg/kg after 2 hours; Group 4 drank cholesterol oil + reagent dose 672 mg/kg after 2 hours; Group 5 drank cholesterol oil + atorvastatin dose 10 mg/kg after 2 hours. Evaluation index: Triglycerides (TG), total cholesterol (TC), HDL-C, LDL-C, VLDL-C, atherosclerotic index (AI) at times 0, 14 and 28 days. Data were processed by SPSS 16.0 software. Results: Groups that used cholesterol oil increased TG, TC, LDL-C, VLDL-C, and AI. Groups 3, 4, and 5 reduced TG, TC, LDL-C, VLDL-C, AI and increased HDL-C compared to group 2 on the 14^th and 28^th days (p < 0,05). Conclusion: Both reagent doses have good effect in treating dyslipidemia, equivalent to the reference group used Atorvastatin.