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RESEARCH ON THE MANUFACTURE OF PHYTOSOME SILYBIN POWDER USING THE SPRAY DRYING METHOD
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Abstract
Objectives: To investigate factors affecting the process of manufacturing phytosome silybin powder from nano phytosome silybin suspension by centrifugal spray drying to improve the stability and dissolution of nano phytosome silybin. Methods: Spray drying to manufacture dry powder by LPG-5 equipment from nano phytosome silybin suspension. Investigate the influencingfactors of the spray drying process, including the type of excipients (maltodextrin, aerosil), excipient/material ratio, inlet gas temperature, and spray speed. Results: The parameters of the spray drying phase include: Aid excipients: MD/AE (80/20); excipients/material ratio: 0.5/1; inlet air temperature: 140ºC; fluid delivery rate: 10 mL/min. The phytosome silybin powder (M7) having moisture was 3.46 ± 0.1%, apparent density was 0.416 ± 0.02 g/mL, Carr’s index was 19.33 ± 0.83%, the total silybin content was 13.97 ± 0.46%, phytosomal silybin content was 12.82 ± 0.27%. Conclusion: A process of manufacturing phytosome silybin powder using spray drying method has been developed for the application of solid oral dosage forms.
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Keywords
Phytosome silybin, Spray drying, Maltodextrin
References
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