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Date Published: 27/11/2023
Abstract Views: 83
Views PDF: 91
DOI: https://doi.org/10.56535/jmpm.v48.476
Issue
Vol. 48 (2023): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ - SỐ CHUYÊN ĐỀ DƯỢC HỌC NĂM 2023
Section
Hội nghị khoa học chuyên ngành Dược
How to Cite
Đặng, T. G., Hồ, B. N. M., Phạm, K. A., Vũ, B. D., & Phạm, V. H. (2023). EVALUATION OF FACTORS AFFECTING THE HYDRATION PROCESS OF MANUFACTURING NANO PHYTOSOME SILYBIN SUSPENSION. Journal of Military Pharmaco-medicine, 48, 77-87. https://doi.org/10.56535/jmpm.v48.476

EVALUATION OF FACTORS AFFECTING THE HYDRATION PROCESS OF MANUFACTURING NANO PHYTOSOME SILYBIN SUSPENSION

Trường Giang Đặng, Bá Ngọc Minh Hồ, Kỳ Anh Phạm, Bình Dương Vũ, Văn Hiển Phạm

Main Article Content

Abstract

Objectives: To evaluate some factors on the properties affecting nano phytosome suspension in the film hydration of silybin - phosphatidylcholine complex. Methods: Nano suspension was prepared using hydration method in the external phase; the effect of solvent type, solvent volume, ultrasonic conditions on particle size, stability of system, entrapment efficiency, solubility and dissolution of the drug were investigated. Results: With the external phase of water at the ratio of 8:1, ultrasonic waves with a power of 720W for 10 minutes, the obtained silybin phytosome nanoparticle suspension had a particle size of 179.3 ± 8.3nm with PDI < 0.5, absolute value of Zeta potential > 30mV. The solubility of silybin in the phytosome nano form increased by 1.64 times compared to the complex form, and the nano phytosome form significantly improved the rate and extent of solubilization of silybin at pH 1.2 and pH 6.8 solution compared with the complex form. Conclusion: The parameters of silybin phytosome nano-suspension were investigated and selected using film hydration method and ultrasonic probe.

Article Details

Keywords

Nano suspension, Phytosome, Film hydration, Ultrasonic probe

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