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Date Published: 27/11/2023
Abstract Views: 140
Views PDF: 111
DOI: https://doi.org/10.56535/jmpm.v48.468
Issue
Vol. 48 (2023): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ - SỐ CHUYÊN ĐỀ DƯỢC HỌC NĂM 2023
Section
Hội nghị khoa học chuyên ngành Dược
How to Cite
Trần, B. H., Vũ, T. A., Bùi, T. T. H., & Lê, V. M. (2023). DETERMINATION OF THE CARDIOPROTECTIVE EFFECTS OF S-PROPARGYL-CYSTEINE IN RATS INDUCED ACUTE MYOCARDIAL INFARCTION. Journal of Military Pharmaco-medicine, 48, 66-76. https://doi.org/10.56535/jmpm.v48.468

DETERMINATION OF THE CARDIOPROTECTIVE EFFECTS OF S-PROPARGYL-CYSTEINE IN RATS INDUCED ACUTE MYOCARDIAL INFARCTION

Bá Hiếu Trần , Tuấn Anh Vũ, Thị Thu Hà Bùi, Văn Minh Lê

Main Article Content

Abstract

Objectives: To determine the cardioprotective effects of S-propargyl-cysteine (SPRC) in rats induced acute myocardial infarction. Methods: Myocardial infarction (MI) was induced in rats by ligating the left anterior descending coronary artery. The concentrations of creatine kinase (CK), lactate dehydrogenase (LDH), and TTC (2, 3, 5-triphenyl tetrazolium chloride) staining were used to evaluate the cardioprotective effects of SPRC. The levels of superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) were used to determine the antioxidant mechanism of SPRC. Results: Preventive treatment with SPRC significantly reduced infarct size, CK, and LDH leakage. SPRC displayed antioxidant properties by preserving SOD and CAT levels while reducing MDA levels. Conclusion: SPRC demonstrated protective effects against MI via an antioxidant mechanism, and its cardioprotective impact was comparable to Captoril.

Article Details

Keywords

S-propargyl-cysteine, Cardioprotective, Myocardial infarction

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