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Date Published: 20/12/2023
Abstract Views: 77
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DOI: https://doi.org/10.56535/jmpm.v48i9.455
Issue
Vol. 48 No. 9 (2023): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 9 - 2023
Section
Articles
How to Cite
Nguyễn, T. T., Phạm, A. K., & Nguyễn, T. N. T. (2023). EVALUATION OF THE EFFECT OF LIGHT ON THE STABILITY OF PROGESTERONE SOLUTION. Journal of Military Pharmaco-medicine, 48(9), 24-35. https://doi.org/10.56535/jmpm.v48i9.455

EVALUATION OF THE EFFECT OF LIGHT ON THE STABILITY OF PROGESTERONE SOLUTION

Thạch Tùng Nguyễn , An Khánh Phạm, Thị Ngọc Thơ Nguyễn

Main Article Content

Abstract

Objectives: To evaluate the effect of light on the stability of progesterone solution; thereby, determining suitable stabilizers for this drug. Methods: Different samples containing the drug were prepared and stored in accelerated conditions, including exposure to UV light at 254nm with added H2O2. The drug concentrations in these samples after predetermined periods were evaluated by high-performance liquid chromatography. Results: Progesterone was degraded by light and oxygen, of which the main mechanisms were direct photolysis and photosensitive auto-reaction. Furthermore, DL-methionine and disodium edetate were proven effective stabilizers for progesterone. Conclusion: The study has evaluated the light effect on progesterone’s stability.

Article Details

Keywords

Progesterone, Photostability

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