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Date Published: 22/08/2023
Abstract Views: 77
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DOI: https://doi.org/10.56535/jmpm.v48i6.377
Issue
Vol. 48 No. 6 (2023): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 6 - 2023
Section
Articles
How to Cite
Phạm, T. N., Trịnh , Q. T., Trịnh, T. S., & Đinh, T. H. (2023). ASSESSMENT OF THE EFFECTS OF ORAL ESTROGEN AND TRANSDERMAL ESTROGEN ON SEVERAL COAGULATION FACTORS OF FROZEN EMBRYO TRANSFER CYCLES IN THE MILITARY INSTITUTE OF CLINICAL EMBRYOLOGY AND HISTOLOGY. Journal of Military Pharmaco-medicine, 48(6), 49-57. https://doi.org/10.56535/jmpm.v48i6.377

ASSESSMENT OF THE EFFECTS OF ORAL ESTROGEN AND TRANSDERMAL ESTROGEN ON SEVERAL COAGULATION FACTORS OF FROZEN EMBRYO TRANSFER CYCLES IN THE MILITARY INSTITUTE OF CLINICAL EMBRYOLOGY AND HISTOLOGY

Thị Nguyệt Phạm, Quốc Thành Trịnh , Thế Sơn Trịnh, Trọng Hà Đinh1,
1 Học viện Quân y

Main Article Content

Abstract

Objectives: To assess the effects of oral estrogen and transdermal estrogen on several coagulation factors in endometrial preparation (EP) of frozen embryo transfer cycles. Methods: A prospective descriptive study on 49 couples with indications for frozen embryo transfer at the Military Institute of Clinical Embryology and Histology from October 2021 to July 2022. Subjects were randomly divided into two groups. Group one used oral estradiol, and group two used transdermal estradiol. PT(s), aPTT(s), and Antithrombin III(%) index were assessed before and after EP with exogenous estradiol in 2 groups. Results: Before EP, the PT, APTT, and AT III were not different between the two groups (p > 0.05); in group one, APTT after EP (29.35 ± 1.72) was lower than before EP (30.63 ± 1.52) with statistical significance (p < 0.05), while PT, AT III, has no difference (p > 0.05); in group two, APTT post-EP (30.24 ± 1.72) was lower than pre-EP (31.03 ± 2.26) with statistical significance (p < 0.05), while PT, AT III  has no difference (p > 0.05); in the uterine EP stage, PT, APTT, AT III had no difference between two groups (p > 0.05). Conclusion: APTT after EP was significantly lower than before EP, which was statistically significant in the two groups. There was no difference between the two groups in coagulation indices such as PT, APTT, and AT III.

Article Details

Keywords

Estrogen, Estradiol, 17β-Estradiol, Frozen embryo transfer, Coagulation factors

References

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