KHẢO SÁT ĐẶC ĐIỂM BIỂU LỘ DẤU ẤN BỀ MẶT VÀ HOẠT TÍNH TẾ BÀO GIẾT TỰ NHIÊN MÁU NGOẠI VI TRÊN BỆNH NHÂN UNG THƯ VÚ THỂ BỘ BA ÂM TÍNH

Abstract

Objectives: To investigate the immunological characteristics of peripheral blood natural killer (NK) cells in patients with triple-negative breast cancer (TNBC) and other types. Subjects and methods:  A cross-sectional descriptive study on 132 cancer patients treated at Vietnam National Cancer Hospital (Tan Trieu campus) from 8/2020 to 6/2022. We analyzed the immunological characteristics of NK cells by flow cytometry and also investigated some tumor markers in the plasma. We evaluated NK cell activity (NKA-IFNg) using the commercial kit NK VUE TestÒ. Results: The rate of TNBC was 16.7% (22/132 cases), with NKA-IFNg being 1202.27 ± 1186.34 pg/mL. TNBC patients having very low NKA-IFNg (less than 200 pg/mL) accounted for 32% of total TNBC patients (7/22 cases). There were no differences in the number, percentage, or expression level of NKG2D activating receptor and NKG2A inhibitory receptor, NKA-IFNg, among different breast cancer histopathological subtypes. Conclusion: For the TNBC group, peripheral blood NK cells have the following characteristics: (1) NKA-IFNg of NK cells is 1202.27 ± 1186.34 (pg/mL), in which the group of very-low NKA-IFNg (≤ 200 pg/mL) accounted for 32% of the TNBC subjects studied. (2) There was no difference in immunological characteristics and NK cell secretory activity among different breast cancer histopathological subtypes.