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Date Published: 28/02/2023
Abstract Views: 101
Views PDF: 87
DOI: https://doi.org/10.56535/jmpm.v48i2.279
Issue
Vol. 48 No. 2 (2023): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 2 - 2023
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Articles
How to Cite
Phạm, H. K., Dương, Q. H., Nguyễn, Q. D., Trần, T. H. T., & Vũ, V. K. (2023). STUDY ON THE PRESENCE OF OIPA AND DUPA GENES OF HELICOBACTER PYLORI IN GASTRIC CANCER PATIENTS. Journal of Military Pharmaco-medicine, 48(2), 73-80. https://doi.org/10.56535/jmpm.v48i2.279

STUDY ON THE PRESENCE OF OIPA AND DUPA GENES OF HELICOBACTER PYLORI IN GASTRIC CANCER PATIENTS

Pham Hong Khanh1, , Duong Quang Huy1, Nguyen Quang Duat1, Tran Thi Huyen Trang2, Vu Van Khien2
1 Military Medical Hospital 103, Vietnam Military Medical University
2 Central Military Hospital 108

Main Article Content

Abstract

Objectives: To determine the percentage of Helicobacter pylori (H. pylori) carrying the outer inflammatory protein A (oipA), duodenal ulcer promotion (dupA) genes, and their relationship with endoscopic imaging, histopathology, and the risk of gastric cancer (GC). Subjects and methods: A cross-sectional study on 89 GC patients, compared with 90 patients with chronic gastritis (CG) with H. pylori infection, diagnosis based on histopathological results at Military Hospital 103 and Central Military Hospital 108 from August 2019 to May 2022. Determination of oipA, dupA genes of H. pylori by realtime-PCR technique on biopsy tissue samples of the gastric mucosa. Results: The percentage of H. pylori carrying the oipA and dupA genes was 30.2% and 10.1%, respectively. The relationship between bacterial infection harboring these 2 genes and endoscopic images and histopathology of GC has not been recorded. There was no difference in the prevalence of H. pylori carrying the oipA and dupA genes infection between the GC and CG groups (p > 0.05). Conclusion: The infection of H. pylori with oipA and dupA genes positive may not increase GC risk in Vietnamese.

Article Details

Keywords

Helicobacter pylori, oipA, dupA, Gastric cancer (GC), Chronic gastritis (CG)

References

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