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Date Published: 28/01/2023
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DOI: https://doi.org/10.56535/jmpm.v48i1.245
Issue
Vol. 48 No. 1 (2023): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 1 - 2023
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Articles
How to Cite
Trinh, Q. T., Trịnh, T. S., Pham, T. N., & Dinh, T. H. (2023). ASSESSMENT OF THE EFFECTS OF ORAL ESTROGEN AND TRANSDERMAL ESTROGEN IN ENDOMETRIAL PREPARATION OF FROZEN EMBRYO TRANSFER CYCLES AT MILITARY INSTITUTE OF CLINICAL EMBRYOLOGY AND HISTOLOGY. Journal of Military Pharmaco-medicine, 48(1), 27-34. https://doi.org/10.56535/jmpm.v48i1.245

ASSESSMENT OF THE EFFECTS OF ORAL ESTROGEN AND TRANSDERMAL ESTROGEN IN ENDOMETRIAL PREPARATION OF FROZEN EMBRYO TRANSFER CYCLES AT MILITARY INSTITUTE OF CLINICAL EMBRYOLOGY AND HISTOLOGY

Trinh Quoc Thanh, Trịnh Thế Sơn, Pham Thi Nguyet , Dinh Trong Ha

Main Article Content

Abstract

Objectives: To access the effects of oral estrogen and transdermal estrogen in endometrial preparation of frozen embryo transfer cycles. Subjects and methods: A prospective descriptive study on 49 couples with indications for frozen embryo transfer at Military Institute of Clinical Embryology and Histology from October 2021 to July 2022. All patients who met the criteria and agreed to participate in the study, were randomly divided into two groups. Group 1 used oral estradiol as estradiol valerate for endometrial preparation, while transdermal estradiol as 17β-Estradiol was used in group 2. Results: The average dose of 17β-Estradiol on the day of "window implantation" was 5.91 ± 0.76 mg/day, equivalent to 7.88 ± 1.01 mg of estradiol valerate, which was significantly higher than the dose of estradiol valerate used in the oral group (7.25 ± 1.15 mg/day, p < 0.05). The thickness of the uterine endometrium in the oral and transdermal estrogen groups was 9.52 ± 0.94 mm and 9.66 ± 0.89 mm, respectively (p > 0.05). The pregnancy rate (positive β-hCG) was similar between the oral estradiol group and the topical estradiol group, 58.8% and 55.6%, respectively (p > 0.05). Conclusion: Transdermal estrogen supplementation has endometrial growth and implantation efficacy comparable to oral estrogen in frozen embryo transfer cycles.

Article Details

Keywords

Estrogen, Estradiol, 17β-Estradiol, Oestrogel, Frozen embryo transfer

References

1. Singh B., Reschke L., Segars J., et al. (2020). Frozen-thawed embryo transfer: the potential importance of the corpus luteum in preventing obstetrical complications. Fertil Steril; 113(2):252-257.
2. Ghobara T., Gelbaya T.A., Ayeleke R.O. (2017). Cycle regimens for frozen-thawed embryo transfer. Cochrane Database Syst Rev; 7, CD003414.
3. Navot D., Laufer N., Kopolovic J., et al. (1986). Artificially induced endometrial cycles and establishment of pregnancies in the absence of ovaries. N Engl J Med; 314(13):806-811.
4. Shahrokh Tehraninejad E., Kabodmehri R., Hosein Rashidi B., et al. (2018). Trans dermal estrogen (oestrogel) for endometrial preparation in freeze embryo transfer cycle: An RCT. Int J Reprod Biomed; 16(1):51-56.
5. Davies M.C., Anderson M.C., Mason B.A., et al. (1990). Oocyte donation: the role of endometrial receptivity. Hum Reprod; 5(7):862-869.
6. Madero S., Rodriguez A., Vassena R., et al. (2016). Endometrial preparation: effect of estrogen dose and administration route on reproductive outcomes in oocyte donation cycles with fresh embryo transfer. Hum Reprod; 31(8):1755-1764.
7. Garimella S., Karunakaran S., Gedela D.R. (2021). A prospective study of oral estrogen versus transdermal estrogen (gel) for hormone replacement frozen embryo transfer cycles. Gynecol Endocrinol; 37(6):515-518.