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Issue: Vol. 51 No. 10 (2026): JOURNAL OF MILITARY PHARMACO-MEDICINE No.10 - 2026
Section: Articles
DOI: 10.56535/jmpm.v51i10.2356
Date Published: 28/10/2026
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How to Cite
Ha, V. G., Nguyen, V. H., Nghiem, L. H. T., Do, T. H. L., Nguyen, D. D., Tran, H. T., Nguyen, H. N., & Tran, H. P. (2026). GASTROPROTECTIVE EFFECT OF VH GASTRIC POWDER ON AN EXPERIMENTAL MODEL. Journal of Military Pharmaco-medicine, 51(10), 114-122. https://doi.org/10.56535/jmpm.v51i10.2356

GASTROPROTECTIVE EFFECT OF VH GASTRIC POWDER ON AN EXPERIMENTAL MODEL

Van Giap Ha1, Viet Hung Nguyen2, , Le Huyen Trang Nghiem3, Thi Huong Lan Do1, Dinh Dung Nguyen4, Hai Trung Tran1, Hoang Ngan Nguyen1, Hoang Phuong Tran5
1 Vietnam Military Medical University
2 Thanh Do University
3 Military Region 4 School
4 VietNam University Of Traditional Medicine
5 108 Military Central Hospital

Main Article Content

Abstract

Objectives: To evaluate the gastroprotective effect of VH Gastric Powder on an experimental gastric ulcer model induced by aspirin combined with pyloric ligation in Wistar rats. Methods: This was an in vivo experimental study design. Fifty Wistar rats were randomly assigned to five groups (n = 10 per group): Group 1 (normal control); Group 2 (ulcer model); Group 3 (omeprazole 20 mg/kg/day); Group 4 (VH Gastric Powder at doses of 4.8 g/kg/day) and Group 5 (VH Gastric Powder, 9.6 g/kg/day). Gastric ulcers were induced by oral administration of aspirin (200 mg/kg) combined with pyloric ligation. Gastric juice volume, pH, free acidity, total acidity, ulcer index, and gross and histopathological changes of the gastric mucosa were evaluated. Results: At both dose levels, VH Gastric Powder significantly reduced gastric juice volume, free acidity, and total acidity, increased gastric juice pH, and decreased the ulcer index by 24.18% and 36.30%, respectively, compared with the ulcer model group (Group 2) (p < 0.05). In addition, the treatment markedly improved both gross and histopathological gastric mucosal lesions. No statistically significant differences were observed between the VH Gastric Powder-treated groups and the omeprazole group (p > 0.05). Conclusion: VH Gastric Powder exhibited significant gastroprotective effects against aspirin- and pyloric ligation-induced gastric ulcers in Wistar rats. 

Keywords

Gastric ulcer, VH Gastric Powder, Gastroprotection, Wistar rats, Aspirin, Pyloric ligation

Article Details

References

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