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Issue: Vol. 51 No. 10 (2026): JOURNAL OF MILITARY PHARMACO-MEDICINE No.10 - 2026
Section: Articles
DOI: 10.56535/jmpm.v51i10.2332
Date Published: 28/10/2026
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Nguyen, T. V. A., Phan, T. T. H., Duong, T. H. Y., Hoang, V. D., Phan, V. K., & Bui, H. T. (2026). INVESTIGATION ON THE LIMONOID CONSTITUENTS FROM THE LEAVES OF CHUKRASIA TABULARIS A. JUSS. Journal of Military Pharmaco-medicine, 51(10), 57-65. https://doi.org/10.56535/jmpm.v51i10.2332

INVESTIGATION ON THE LIMONOID CONSTITUENTS FROM THE LEAVES OF CHUKRASIA TABULARIS A. JUSS.

Thi Viet Ai Nguyen1,2, Thi Thanh Huong Phan3, Thi Hai Yen Duong3, Viet Dung Hoang4, Van Kiem Phan2,3, Huu Tai Bui2,3,
1 Graduate University of Sciences and Technology
2 National Institute of Drug Quality Control
3 Institute of Chemistry
4 Vietnam Military Medical University

Main Article Content

Abstract

Objectives: To primarily investigate the limonoid constituents of the leaves of  Chukrasia  tabularis  A.  Juss.,  Meliaceae  family,  collected  in  Son  La  province. Methods: This was an in vitro experimental study design. Compounds were isolated and purified by chromatographic techniques as well as semi-preparative HPLC. The isolated compounds were structurally elucidated by comprehensive spectroscopic analyses of 1D and 2D NMR, HRESIMS and comparison with reported data. Results: Three orthoester derivatives of phragmalin-type limonoid were isolated and identified as tabularisin N (compound 1), tabulalide D (compound 2), and 3,30-diisobutyryl-12-acetoxyphragmalin (compound 3). Conclusion: This study enriches the phytochemical knowledge of C. tabularis in Vietnam, providing additional evidence that this species is a valuable source of structurally diverse limonoids for future phytochemical and biological investigations.

Keywords

Chukrasia tabularis, Meliaceae family, Orthoester, Phragmalin limonoid

Article Details

References

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