PHÂN TÍCH MỘT SỐ VẤN ĐỀ LIÊN QUAN ĐẾN THUỐC TRONG KÊ ĐƠN KHÁNG SINH TẠI KHỐI NGOẠI, BỆNH VIỆN QUÂN Y 105 NĂM 2025

Abstract

Objectives: To analyze drug-related problems (DRPs) in antibiotic prescriptions at the Surgical Department, Military Hospital 105 in 2025. Methods: A retrospective, descriptive study was conducted on 400 inpatient records with antibiotic use (3,888 antibiotic prescription items out of 16,435 total drug prescription items) at the Surgical Departments, Military Hospital 105 in 2025. Results: Among 400 inpatient records, the proportion of male patients was higher than that of female patients (59.0% vs. 41.0%); patients aged ≥ 60 years accounted for 33.5%; the mean duration of antibiotic use was 7.67 ± 5.05 days; 28.5% of patients received combination antibiotic therapy. DRPs related to dosage accounted for the highest proportion (73.3%), mainly insufficient frequency of use (67.5%); suboptimal antibiotic selection accounted for 36.3%; drug interactions were observed in 71 cases (17.8%), with 241 pairs-incidents (93.8% were moderate and only 5 cases (1.3%) had serious interactions); inappropriate antibiotic combinations were observed in 60 cases (15.0%). Conclusion: The main DRPs groups in antibiotic prescriptions at the Surgical Departments, Military Hospital 105 have been identified, focusing on the two DRPs namely insufficient frequency of use and suboptimal antibiotic selection. Most identified drug interactions were of moderate severity and could be managed through targeted monitoring and order adjustments. Clinical pharmacy activities need to be strengthened to ensure timely detection and intervention.