NGHIÊN CỨU ĐIỀU CHẾ VÀ KIỂM TRA CHẤT LƯỢNG MACROAGGREGATED ALBUMIN GẮN ĐỒNG VỊ PHÓNG XẠ 99mTc

Abstract

Introduction: Human serum albumin (HSA) is used in the preparation of macroaggregated albumin (MAA), which is studied on the optimized conditions labeling with ^99mTc. Objectives: To present the results in the production of  ^99mTc-MAA used in lung perfusion scintigraphy and pre-dose in the liver treatment process using ⁹⁰Y-microspheres. Subjects and methods: The albumin macroaggregates were prepared from 0.3% HSA in 5% sodium chloride, pH 6, by heating a mixture of instant precipitation under 80 - 90°C. The MAA was centrifuged filter and particle sizing. The labeling optimization was conducted, such as stannous chloride and pH. ^99mTc-MAA was tested for radiolabeling yield, radiochemical purity, and stability. Results: The MAA formulation kit contained 30 mg MAA, 20 - 50 µm particle size, 0.5 mg stannous chloride, pH 5. The radiolabeling yields of ^99mTc-MAA were more than 95% and radiochemical purity was > 98%. Conclusion: ^99mTc-MAA is an ideal radiopharmaceutical in lung perfusion scintigraphy and other cancer.