BIẾN ĐỔI NỒNG ĐỘ MỘT SỐ CYTOKINE HUYẾT TƯƠNG TRƯỚC VÀ SAU ĐIỀU TRỊ LAO TIỀM ẨN Ở BỆNH NHÂN LỌC MÁU CHU KỲ

Abstract

Objectives: To evaluate changes in plasma cytokine concentrations of IFN-γ, TNF-α, IL-6, and CXCL-10 in end-stage renal disease (ESRD) patients on maintenance hemodialysis with latent tuberculosis infection (LTBI) after 3 months of treatment. Methods: A descriptive longitudinal study was conducted on 33 ESRD on maintenance hemodialysis with LTBI treated at Military Hospital 103 from August 2023 to December 2025. Plasma cytokine levels were quantified using the ELISA method before and after LTBI treatment. Patients with LTBI received the 3RH regimen and were reassessed after 3 months. Results: After 3 months of LTBI treatment, TNF-α levels and IL-6 levels showed a decreasing trend compared with baseline from 23.10 to 20.80 pg/mL and from 3.20 to 1.41 pg/mL, respectively; however, the differences were not statistically significant (p > 0.05). IFN-γ and CXCL-10 levels showed minimal changes after treatment. In the subgroup of patients with QuantiFERON-TB (QFT) conversion from positive to negative, TNF-α levels decreased significantly after treatment (from 18.40 to 4.69 pg/mL; p = 0.027). Conclusion: After 3 months of LTBI treatment in hemodialysis patients, there was no statistically significant change in plasma levels of IFN-γ, TNF-α, IL-6, and CXCL-10; however, a statistically notable reduction in TNF-α levels was observed in patients with QFT conversion from positive to negative.