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Date Published: 18/01/2023
Abstract Views: 148
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DOI: https://doi.org/10.56535/jmpm.v47i9.214
Issue
Vol. 47 No. 9 (2022): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 9 - 2022
Section
Articles
How to Cite
Phan , D. C., Nguyen, T. H. T., Ngo, T. X. T., Dang, T. T., Vu, B. D., & Nguyen, T. H. T. (2023). SYNTHESIS OF MEMANTINE HYDROCHLORIDE BY DIRECT AMINOATION OF 1-BROMO-3,5-DIMETHYLADAMANTANE WITH. Journal of Military Pharmaco-medicine, 47(9), 140-148. https://doi.org/10.56535/jmpm.v47i9.214

SYNTHESIS OF MEMANTINE HYDROCHLORIDE BY DIRECT AMINOATION OF 1-BROMO-3,5-DIMETHYLADAMANTANE WITH

Phan dinh Chau1, Nguyen Thi Hong Thanh2, Ngo Thi Xuan Thu3, Dang Thi Thuy3, Vu Binh Duong, Nguyen Thi Hong Tham4,
1 Hanoi University of Science and Technology
2 Vinh Medical University
3 108 Military Central Hospital
4 Le Huu Trac National Burn Hospital

Main Article Content

Abstract

Objectives: To optimize the synthesis process of memantine hydrochloride by direct aminoation of 1-bromo-3,5-dimethyladamantane with urea. Materials and methods: Using the basic chemical reactions to optimize the reaction conditions. Results: The optimal conditions of the memantine hydrochloride synthesis process include: The reaction solution was diphenyl ether; the reaction temperature was 170oC within 4 hours (in the first step) and 100oC within 2 hours (in the second step); the molar ration of 1-bromo-3,5-dimethyladmantane: urea: diphenyl ether was 1:3:2.5; the duration of the reaction was 6 hours and the overall yields were 75.81%. Conclusion: The synthesis process of memantine hydrochloride by direct aminoation with urea was established. The finished products were determined by IR, MS, and NMR spectra and met the standards of USP 43.

Article Details

Keywords

Memantine hydrochloride, Urea, 1-bromo-3,5-dimethyladamantane, Synthesis, Amioation, Alzheimer's disease

References

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