VAI TRÒ CỦA BẤT ĐỐI XỨNG NĂNG LƯỢNG SÓNG TUYỆT ĐỐI GIỮA HAI BÁN CẦU NÃO TRONG PHÁT HIỆN TRẦM CẢM

Abstract

Objectives: To evaluate the role of interhemispheric asymmetry of absolute electroencephalography (EEG) power in the detection of depression. Methods: A prospective, descriptive, cross-sectional study was conducted on 90 adult patients with depressive disorder and 90 healthy controls. Both groups were age-and sex-matched (ranging from 18 - 60 years old). Monopolar EEG recordings were obtained for 20 minutes at 12 scalp locations. EEG data were analyzed using the EEGLAB toolbox in MATLAB R2022b software. Results:Global interhemispheric asymmetry of alpha power (left hemisphere higher than right hemisphere), as well as higher left-than-right hemisphere asymmetry in central beta waves and parietal theta waves, were observed (p < 0.05). This increased power was independently associated with the risk of depression; specifically for alpha waves (OR = 2.71; 95%CI: 1.05 - 3.96), beta waves (OR = 5.50; 95%CI: 1.85 - 16.31), and theta waves (OR = 3.77; 95%CI: 1.40 - 10.16), respectively. Conclusion: Higher absolute power in the left hemisphere compared to the right hemisphere for global alpha waves, central beta waves, and parietal theta waves may serve as potential biomarkers for the detection and diagnosis of depression.