VAI TRÒ CỦA MỘT SỐ THÔNG SỐ CHUYỂN HÓA ¹⁸F-FDG PET/CT TRONG DỰ ĐOÁN ĐÁP ỨNG HÓA XẠ TRỊ ĐỒNG THỜI Ở NGƯỜI BỆNH UNG THƯ THỰC QUẢN GIAI ĐOẠN III

Abstract

Objective: To study the role of several ¹⁸F-FDG PET/CT metabolic parameters in predicting treatment response after concurrent chemoradiotherapy (CRT) in patients with stage III esophageal cancer. Methods: A retrospective and prospective, descriptive study was conducted on 91 patients with stage III esophageal cancer who underwentPET/CT scan before concurrent chemoradiotherapy. Metabolic parameters, including SUVmax (maximal standard uptake value), MTV (metabolic tumor volume), and TLG (total lesion glycolysis), were measured on ¹⁸F-FDG PET/CT images. Data were entered and processed on SPSS version 27.0. Results: The optimal cut-off values of SUVmax, MTV, and TLG for predicting complete treatment response were 15.7, 22.9, and 257.2, respectively. Univariate analysis showed that SUVmax, MTV, and TLG were all significant predictors of complete treatment response following concurrent chemoradiotherapy at the proposed cut-off values. In multivariate analysis, patients with non-complete responses were significantly associated with SUVmax ≥ 15.7 (OR = 4.3; p < 0.05) and TLG ≥ 257.2 (OR = 2.99; p < 0.05), with sensitivity, specificity, and accuracy of 80.6%, 58.6%, 73.6% and 64.5%, 72.4%, 67%, respectively. Conclusion:The pretreatment SUVmax and TLG of the primary tumor on ¹⁸F-FDG PET/CT may serve as useful predictors of complete treatment response following concurrent chemoradiotherapy in patients with stage III esophageal cancer.