KẾT QUẢ THỤ TINH TRONG ỐNG NGHIỆM Ở PHỤ NỮ TỪ 35 TUỔI TRỞ LÊN TẠI BỆNH VIỆN PHỤ SẢN THANH HÓA

Abstract

Objectives: To evaluate the outcomes of in vitro fertilization (IVF) and to analyze influencing factors in women aged ≥ 35 years. Methods: A retrospective, cross-sectional descriptive study was conducted on 103 women aged ≥ 35 years undergoing IVF who had embryo transfer between 2019 and 2020. Collected variables included baseline patient characteristics, embryological parameters, implantation rate, and clinical pregnancy rate. Associations of maternal age, number of embryos transferred, and endometrial thickness with clinical pregnancy outcomes were analyzed. Results: The mean number of oocytes retrieved was 6.4 ± 4.3, with a fertilization rate of 84.3%. The mean number of embryos obtained was 4.8 ± 2.58. The implantation rate and clinical pregnancy rate were 20.8% and 30.1%, respectively. The clinical pregnancy rate in women aged 35 - 39 years (34.6%) was higher than those aged ≥ 40 years (16%). Transferring ≥ 2 embryos was associated with a 3.3-fold increase in the likelihood of pregnancy compared with single embryo transfer. An endometrial thickness > 11mm was positively associated with a higher clinical pregnancy rate. Conclusion: Maternal age, number of embryos transferred, and endometrial thickness are key determinants of IVF outcomes in women aged ≥ 35 years. Treatment effectiveness declines with advancing age, particularly after 40 years.