ASSOCIATION BETWEEN 5HTR2A T102C GENE VARIANT AND CLINICAL CHARACTERISTICS IN PATIENTS WITH DEPRESSIVE DISORDER
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Abstract
Objectives: To determine the association between the 5HTR2A T102C gene variant and several clinical characteristics in patients with depressive disorder. Methods: A cross-sectional descriptive study analysing 110 patients diagnosed with depressive disorders and treated at the Psychiatry Department, Military Hospital 103 from January 2024 to December 2025. Results: The 5HTR2A T102C variant was associated with the number of relapses, the number of hospitalizations, and the occurrence of panic attacks. The CC genotype had a significantly higher risk of relapse, hospitalization, and panic attacks compared to the genotypes with T allele (TT or TC). The genotype with C allele (CC/TC) had a significantly higher incidence of irritability compared to the TT genotype. Conclusion: The CC 5HTR2A T102C genotype was associated with the number of relapses, hospitalizations, and panic attacks; meanwhile, the 5HTR2A T102C CC or TC genotypes were also associated with irritability.
Keywords
Clinical characteristics, Depressive disorder, 5HTR2A T102C gene variant
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References
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