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Issue: Vol. 51 No. 5 (2026): JOURNAL OF MILITARY PHARMACO-MEDICINE No.5 - 2026
Section: Articles
DOI: 10.56535/jmpm.v51i5.1929
Date Published: 28/05/2026
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Le, K. K., & Nguyen , H. T. (2026). FACTORS ASSOCIATED WITH HEMATOMA EXPANSION IN PATIENTS WITH SPONTANEOUS INTRACEREBRAL HEMORRHAGE. Journal of Military Pharmaco-medicine, 51(5), 148-153. https://doi.org/10.56535/jmpm.v51i5.1929

FACTORS ASSOCIATED WITH HEMATOMA EXPANSION IN PATIENTS WITH SPONTANEOUS INTRACEREBRAL HEMORRHAGE

Kim Khanh Le1, Huy Thang Nguyen 2,3,
1 Vinmec Central Park International Hospital
2 People's Hospital 115
3 Pham Ngoc Thach University of Medicine

Main Article Content

Abstract

Objectives: To determine the correlation between intracerebral hemorrhage (ICH) location (lobar vs. non-lobar) and hematoma expansion (HE) in the acute phase. Methods: A prospective, cross-sectional descriptive, longitudinal study was conducted on 151 patients with spontaneous ICH admitted within the first 6 hours at Nhan Dan Gia Dinh Hospital and People's Hospital 115 from January to September 2020. Patients underwent baseline computed tomography (CT) scans upon admission and a follow-up scan within 36 hours. HE was defined as an increase in hematoma volume of ≥ 33% from baseline. Results: The overall rate of HE was 25.8%. The lobar ICH group had a significantly higher rate of HE compared to the non-lobar group (34.9% vs 18.8%; p = 0.026). Multivariate analysis identified lobar location (p = 0.02) and high initial systolic blood pressure (p = 0.004) as independent predictors of HE. The lobar ICH group also had a higher rate of poor outcomes (mRS > 3) at day 30.  Conclusion: Lobar ICH location is strongly associated with the risk of HE and poorer clinical outcomes at day 30.

Keywords

Intracerebral hemorrhage, Hematoma expansion, Hematoma location, Lobar hemorrhage

Article Details

References

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