PREGNANCY OUTCOMES AND POSTNATAL STATUS OF FETUSES WITH ISOLATED VENTRICULOMEGALY AT HANOI OBSTETRICS AND GYNECOLOGY HOSPITAL

Trong Hung Mai1, Tai Đuc Nguyen1, Hung Nguyen1, Thuy Linh Dinh1,
1 Hanoi Obstetrics & Gynecology Hospital

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Abstract

Objectives: To evaluate the management, pregnancy outcomes, and postnatal status of fetuses with isolated ventriculomegaly at Hanoi Obstetrics and Gynecology Hospital. Methods: A retrospective, cross-sectional descriptive study on 119 pregnant women with fetuses diagnosed with isolated ventriculomegaly from January 2022 to December 2023; these participants were followed until 6 months postpartum. Results: Pregnancy continuation and termination rates were 84% and 16%. Factors associated with pregnancy termination included early gestational age at diagnosis (p < 0.001), severe ventriculomegaly (p < 0.001), bilateral ventriculomegaly (p < 0.001), and genetic abnormalities. 100% of cases with unilateral ventriculomegaly continued pregnancy. In the continuation group, 97.0% of the infants were healthy and required no intervention, 87.9% had resolution of ventriculomegaly after birth, and only 2.0% had persistent ventriculomegaly at 6 months. Conclusion: Most isolated ventriculomegaly pregnancies (84%) were continued with favorable outcomes. Severe ventriculomegaly, bilateral ventriculomegaly, and genetic abnormalities influenced the decision of pregnancy termination. Mild and unilateral isolated ventriculomegaly had a favorable prognosis.

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References

1. Salomon LJ, Bernard JP, Ville Y. Reference ranges for fetal ventricular width: A non-normal approach. Ultrasound Obstet Gynecol. 2007; 30:61-66.
2. Weichert J, Hartge D, Krapp M, et al. Prevalence, characteristics and perinatal outcome of fetal ventriculomegaly in 29,000 pregnancies followed at a single institution. Fetal Diagn Ther. 2010; 27:142-148.
3. Wax JR, Bookman L, Cartin A, et al. Mild fetal cerebral ventriculomegaly: Diagnosis, clinical associations, and outcomes. Obstet Gynecol Surv. 2003; 58:407-414.
4. Laskin MD, Kingdom J, Toi A, et al. Perinatal and neurodevelopmental outcome with isolated fetal ventriculomegaly: A systematic review. J Matern Fetal Neonatal Med. 2005; 18:289-298.
5. Gaglioti P, Danelon D, Bontempo S, et al. Fetal cerebral ventriculomegaly: Outcome in 176 cases. Ultrasound Obstet Gynecol. 2005; 25:372-377.
6. Scala C, Familiari A, Pinas A, et al. Perinatal and long-term outcomes in isolated mild fetal ventriculomegaly: Systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2017; 49(4):450-459.
7. Nan Chu, Yueping Zhang, Yingliu Yan, et al. Fetal ventriculomegaly: Pregnancy outcomes and follow-ups in ten years. Biosci Trends. 2016; 10(2):125-132.
8. Norton ME, Fox NS, Monteagudo A, et al. Fetal ventriculomegaly. Society for Maternal-Fetal Medicine (SMFM). Am J Obstet Gynecol. 2020; 223(6):B30-B35.
9. Trần Phương Thanh, Trần Danh Cường. Nghiên cứu chẩn đoán trước sinh và kết cục thai nghén của thai nhi có GNT được phát hiện ở quý 3 thai kỳ. Luận văn Thạc sĩ Y học. Đại học Y Hà Nội. 2018.
10. Griffiths PD, Reeves MJ, Morris JE, et al. A prospective study of fetuses with isolated ventriculomegaly investigated by antenatal sonography and in utero MR imaging. AJNR Am J Neuroradiol. 2010; 31:106-111.