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Date Published: 28/03/2026
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DOI: 10.56535/jmpm.v51i3.1885
Issue
Vol. 51 No. 3 (2026): JOURNAL OF MILITARY PHARMACO-MEDICINE No.3 - 2026
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Articles
How to Cite
Pham, V. C., Bui, V. N., Le, H. K., Dinh, Q. T., Vu, T. L., Nguyen, T. K., & Nguyen, T. G. (2026). A CLINICAL CASE REPORT: THROMBOTIC PHENOTYPE DISSEMINATED INTRAVASCULAR COAGULATION FOLLOWING SEVERE SPLENIC TRAUMA - CHALLENGES IN ANTICOAGULATION MANAGEMENT. Journal of Military Pharmaco-medicine, 51(3), 127-134. https://doi.org/10.56535/jmpm.v51i3.1885

A CLINICAL CASE REPORT: THROMBOTIC PHENOTYPE DISSEMINATED INTRAVASCULAR COAGULATION FOLLOWING SEVERE SPLENIC TRAUMA - CHALLENGES IN ANTICOAGULATION MANAGEMENT

Van Cong Pham1, , Van Nghia Bui1, Ha Khoa Le1, Quoc Thinh Dinh1, Tien Luc Vu2, Trung Kien Nguyen3, Truong Giang Nguyen3
1 Học viện Quân y
2 Bệnh viện Đa khoa Ninh Bình
3 Cục Quân y

Main Article Content

Abstract

Objectives: To report a clinical case of thrombotic phenotype disseminated intravascular coagulation (DIC) following severe splenic trauma. Methods: A retrospective research, case report of a 41-year-old male admitted with traumatic shock due to a splenic rupture and rib fractures. The patient underwent an emergency splenectomy, subsequently developed progressive DIC complications, and was treated with anticoagulants (heparin) in combination with intensive blood product resuscitation. Results: The initiation of heparin therapy combined with targeted blood transfusion (aimed at maintaining platelets > 50 G/L, INR < 1.5, and fibrinogen > 1.5 g/L) led to improved visceral perfusion and stabilized coagulation parameters after 6 days of treatment. No hemorrhagic complications were observed throughout the course of anticoagulation. Conclusion: Early diagnosis of thrombotic phenotype DIC based on the International Society on Thrombosis and Haemostasis (ISTH) score and imaging is essential. Controlled use of heparin can be life-saving, even during the postoperative phase.

Keywords

Trauma-induced disseminated intravascular coagulation, Thrombotic phenotype, Anticoagulation

Article Details

References

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