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Date Published: 28/03/2026
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DOI: 10.56535/jmpm.v51i3.1850
Issue
Vol. 51 No. 3 (2026): JOURNAL OF MILITARY PHARMACO-MEDICINE No.3 - 2026
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Articles
How to Cite
Le, Q. T., Nguyen, N. L., & Tran, D. H. (2026). EFFICACY OF PRONE POSITION VENTILATION IN IMPROVING BLOOD OXYGENATION AND CARBON DIOXIDE CLEARANCE IN SEVERE BURN PATIENTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME. Journal of Military Pharmaco-medicine, 51(3), 194-202. https://doi.org/10.56535/jmpm.v51i3.1850

EFFICACY OF PRONE POSITION VENTILATION IN IMPROVING BLOOD OXYGENATION AND CARBON DIOXIDE CLEARANCE IN SEVERE BURN PATIENTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME

Quang Thao Le1,2, , Nhu Lam Nguyen1,2, Dinh Hung Tran1,2
1 Bộ môn Bỏng và Y học Thảm họa, Học viện Quân y
2 Bệnh viện Bỏng Quốc gia Lê Hữu Trác, Học viện Quân y

Main Article Content

Abstract

Objectives: To evaluate the efficacy of prone position ventilation (PPV) in improving blood oxygenation and carbon dioxide clearance in severe burn patients with acute respiratory distress syndrome (ARDS). Methods: A prospective, descriptive, longitudinal study was conducted in 48 adult patients with severe burn ARDS treated with PPV at the Intensive Care Unit, Le Huu Trac National Burn Hospital, from January 2023 to December 2025. Data were recorded at the following time points: Before PPV (T0), and at 1 hour (T1), 6 hours (T6), 12 hours (T12), and 16 hours (T16) during PPV. Results: The PaO₂/FiO₂ ratio increased significantly from 128.0 ± 2.1mmHg at T0 to 133.9 ± 2.1mmHg at T1 (p = 0.0003) and peaked at T16 (159.6 ± 2.1mmHg). The oxygenation index (OI) decreased progressively showing a significant reduction at T1 compared with T0 (17.10 ± 0.43 vs. 16.45 ± 0.43; p = 0.0365), reaching its lowest point at T16 (14.66 ± 0.43). Regarding PaCO₂, the mean value for the overall cohort did not change significantly over time (p > 0.05). However, among patients with inhalation injury, PaCO₂ declined progressively and was significantly lower at T16 compared with T0 (47.67 ± 0.66 vs. 48.55 ± 0.66mmHg; p = 0.03). Conclusion: PPV effectively improves blood oxygenation and contributes to arterial CO₂ clearance in severe burn patients with ARDS, particularly in those with inhalation injury.

Keywords

Prone position ventilation, Burn, Acute respiratory distress syndrome, Blood oxygenation

Article Details

References

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