DEVELOPMENT OF A DYNAMIC NOMOGRAM FOR PREDICTING NEUROLOGICAL RECOVERY FOLLOWING TRAUMATIC CERVICAL SPINAL CORD INJURY

Dinh Trung Ngo1, , Van Nam Do1
1 Bệnh viện Trung ương Quân đội 108

Main Article Content

Abstract

Objectives: To develop a web-based dynamic nomogram for individualized prediction of neurological recovery at 1 year in patients undergoing surgery for traumatic cervical spinal cord injury (TCSCI). Methods: A retrospective, descriptive, single-center study was conducted on 206 patients with TCSCI who underwent surgery at 108 Military Central Hospital between January 2016 and June 2024. R software and a Shiny web application, a dynamic, interactive nomogram was developed based on a multivariable logistic regression model to predict neurological recovery after TCSCI. Results: The neurological recovery rate at 1 year was 46.6%. 6 variables were incorporated into the prognostic model, including age, degree of cervical spinal canal stenosis, spinal cord lesion length, surgery within 24 hours after injury, intensive care unit length of stay, and tracheostomy. The multivariable logistic regression model demonstrated excellent predictive performance with an AUC of 0.916. A dynamic nomogram for predicting neurological recovery has been developed and is accessible at https://dynnomogramsicu.shinyapps.io/DynomogramTSCI/Conclusion: The dynamic nomogram derived from a multivariable logistic regression model enables individualized prediction of neurological recovery following TCSCI. This prognostic tool may guide therapeutic decision-making, support risk stratification, and optimize rehabilitation planning for surgically treated patients.

Article Details

References

1. Moghaddamjou A, Fehlings MG. The beneficial effect of early surgical decompression for acute spinal cord injury: Time is spine. Neurospine. 2021; 18(1):20.
2. Yamamoto K, Okuda A, Maegawa N, et al. Is early surgical intervention effective for traumatic severe cervical spinal cord injury? A retrospective study secondary publication. Signa Vitae. 2022; 18(4):41-46.
3. Yang C, Wang Q, Xu S, Guan C, Li G, Wang G. Early expansive single sided laminoplasty decompression treatment severe traumatic cervical spinal cord injury. Front Surg. 2022; 9:984899.
4. Feng N, Xu L, Yu X, et al. Case characteristics and surgical efficacy in elderly patients over 65 years of age with cervical spinal cord injury without fracture and dislocation: A retrospective study. BMC Musculoskelet Disord. 2024; 25(1):921.
5. Choy W, Kyritsis N, Fernandez XD, et al. American Spinal Injury Association (ASIA) Impairment Scale (AIS) conversion underestimates neurological recovery following traumatic spinal cord injury. Neurosurgery. 2023; 69(Suppl 1):29.
6. Shimizu T, Suda K, Maki S, et al. Efficacy of a machine learning-based approach in predicting neurological prognosis of cervical spinal cord injury patients following urgent surgery within 24h after injury. J Clin Neurosci. 2023; 107:150-156.
7. Maki S, Furuya T, Inoue T, et al. Machine learning web application for predicting functional outcomes in patients with traumatic spinal cord injury following inpatient rehabilitation. J Neurotrauma. 2024; 41(9-10):1089-1100.