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Date Published: 28/02/2026
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DOI: 10.56535/jmpm.v51i2.1794
Issue
Vol. 51 No. 2 (2026): JOURNAL OF MILITARY PHARMACO-MEDICINE No.2 - 2026
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Articles
How to Cite
Le, Q. G., Do, M. T., Pham, T. T., Nguyen, C., Nguyen, T. D., & Tran, Q. H. (2026). In silico PREDICTION OF ANTIGENIC B-CELL EPITOPES ON FepA PROTEIN OF Acinetobacter baumannii. Journal of Military Pharmaco-medicine, 51(2), 61-70. https://doi.org/10.56535/jmpm.v51i2.1794

In silico PREDICTION OF ANTIGENIC B-CELL EPITOPES ON FepA PROTEIN OF Acinetobacter baumannii

Quynh Giang Le1, , Do Minh Trung2, Pham The Tai2, Nguyen Cuong3,4, Nguyen Tien Dat4, Tran Quang Huu5
1 Vietnam Military Medical Universisty
2 Vietnam Military Medical University
3 Institute of Information Technology, Vietnam Academy of Science & Technology
4 LOBI Vietnam Ltd.
5 Hai Duong Medical Technical University

Main Article Content

Abstract

Objectives: To identify potential B-cell epitopes on the FepA protein from Acinetobacter baumannii (A. baumannii) for vaccine development. Methods: Comprehensive in silico analyses were performed to predict the antigenicity, solubility, and transmembrane topology of FepA, and to identify both linear and conformational B-cell epitopes. The predicted epitopes were subsequently evaluated for allergenicity, toxicity, physicochemical properties, and homology to human proteins. Results: FepA was identified as an outer membrane protein containing 22 transmembrane β-barrels and high antigenicity. The analyses identified the most promising epitopes, including 2 linear epitopes (E3, E9) and 4 conformational epitopes (E12 - E15), which exhibit high immunogenic potential and are suitable for vaccine development. Conclusion: FepA is an epitope-rich antigen and represents a valuable candidate for vaccine development against A. baumannii.

Keywords

Acinetobacter baumannii, FepA protein, B-cell epitope, In silico, Vaccine

Article Details

References

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