Article Sidebar

PDF
Date Published: 28/02/2026
Abstract Views: 0
Views PDF: 0
DOI: 10.56535/jmpm.v51i2.1766
Issue
Vol. 51 No. 2 (2026): JOURNAL OF MILITARY PHARMACO-MEDICINE No.2 - 2026
Section
Articles
How to Cite
Ha, V. H., Nguyen, T. T. H., Tran, T. H., Bui, T. T. T., & Ly, T. H. V. (2026). APPLICATION OF COMBINED ICG AND 99mTc IN SENTINEL LYMPH NODE BIOPSY IN BREAST CANCER SURGERY: LITERATURE REVIEW AND CLINICAL APPLICATION. Journal of Military Pharmaco-medicine, 51(2), 7-14. https://doi.org/10.56535/jmpm.v51i2.1766

APPLICATION OF COMBINED ICG AND 99mTc IN SENTINEL LYMPH NODE BIOPSY IN BREAST CANCER SURGERY: LITERATURE REVIEW AND CLINICAL APPLICATION

Van Huy Ha1, , Thi Thanh Hoa Nguyen1, Thanh Huong Tran1, Thi Thu Trang Bui1, Thi Hong Van Ly1
1 108 Military Central Hospital

Main Article Content

Abstract

Sentinel lymph node biopsy (SLNB) has become a global standard technique for axillary lymph node staging in breast cancer surgery. To achieve high efficiency in SLNB, the choice of lymph node mapping method is receiving increasing interest. The combined use of two sentinel lymph node mapping methods is recommended to increase the detection rate and reduce the false negative rate. The technique of combining 99mTc radioactive isotope with Indocyanine Green (ICG) fluorescent dye demonstrates high efficiency and safety compared to conventional methods. This literature review analyzes the role and application of the combination of 99mTc and ICG for SLNB in breast cancer surgery. Although there have been studies demonstrating high efficiency, further trials are needed to optimize this method and its application in clinical practice.

Keywords

Sentinel lymph node biopsy, Indocyanine Green, 99mTc

Article Details

References

1. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024; 74(3):229-263.
2. Giammarile F, Vidal-Sicart S, Paez D, Pellet O, Enrique EL, Mikhail-Lette M, et al. Sentinel lymph node methods in breast cancer. Semin Nucl Med. 2022; 52(5):551-560.
3. Mariani G, Moresco L, Viale G, Villa G, Bagnasco M, Canavese G, et al. Radioguided sentinel lymph node biopsy in breast cancer surgery. 2001; 42(8):1198-1215.
4. Vermersch C, Raia-Barjat T, Chapelle C, Lima S, Chauleur C. Randomized comparison between indocyanine green fluorescence plus (99m) technetium and (99m) technetium alone methods for sentinel lymph node biopsy in breast cancer. Sci Rep. 2019; 9(1):6943.
5. Manca G, Garau LM, Mazzarri S, Mazzuca L, Muccioli S, Ghilli M, et al. Novel experience in hybrid tracers: Clinical evaluation of feasibility and efficacy in using ICG-99mTc nanotop for sentinel node procedure in breast cancer patients. Clin Nucl Med. 2021; 46(4):e181-e187.
6. Pitsinis V, Kanitkar R, Vinci A, Choong WL, Benson J. Results of a prospective randomized multicenter study comparing Indocyanine Green (ICG) fluorescence combined with a standard tracer versus icg alone for sentinel lymph node biopsy in early breast cancer: The INFLUENCE Trial. Ann Surg Oncol. 2024; 31(13):8848-8855.
7. Nguyen CL, Zhou M, Easwaralingam N, Seah JL, Azimi F, Mak C, et al. Novel dual tracer indocyanine green and radioisotope versus gold standard sentinel lymph node biopsy in breast cancer: The GREENORBLUE Trial. Ann Surg Oncol. 2023; 30(11):6520-6527.
8. Aoyama K, Kamio T, Ohchi T, Nishizawa M, Kameoka S. Sentinel lymph node biopsy for breast cancer patients using fluorescence navigation with indocyanine green. World J Surg Oncol. 2011; 9:157.
9. da Silva Sa R, Von Ah Rodrigues RF, Bugalho LA, da Silva SU, Pinto Nazario AC. Evaluation of the efficacy of using indocyanine green associated with fluorescence in sentinel lymph node biopsy. PLoS One. 2023; 18(10):e0273886.