Article Sidebar

PDF
Date Published: 28/03/2026
Abstract Views: 0
Views PDF: 0
DOI: 10.56535/jmpm.v51i3.1702
Issue
Vol. 51 No. 3 (2026): JOURNAL OF MILITARY PHARMACO-MEDICINE No.3 - 2026
Section
Articles
How to Cite
Le, V. H., Nguyen, V. N., & Hoang, T. A. (2026). EVALUATION OF THE MORPHOLOGY AND ORGAN FUNCTION TOXICITY OF HA-COATED ZK60 SCREW IMPLANTS IN EXPERIMENTAL ANIMALS. Journal of Military Pharmaco-medicine, 51(3), 48-55. https://doi.org/10.56535/jmpm.v51i3.1702

EVALUATION OF THE MORPHOLOGY AND ORGAN FUNCTION TOXICITY OF HA-COATED ZK60 SCREW IMPLANTS IN EXPERIMENTAL ANIMALS

Van Hai Le1, , Van Ninh Nguyen1, Tuan Anh Hoang2
1 Military Hospital 103
2 Bệnh viện Đại học Y Dược - Đại học Quốc gia Hà Nội

Main Article Content

Abstract

Objectives: To evaluate the toxicity of hydroxyapatite (HA)-coated ZK60 screw-plate on the structure and function of the liver, kidneys, and brain in an experimental model. Methods: A cross-sectional descriptive and controlled study was conducted on 84 healthy white rabbits were randomly divided using an Excel file into three groups: Group 1 (n = 28) received HA-coated ZK60 magnesium screw implants; group 2 (n = 28) received uncoated ZK60 screw implants; and group 3 (n = 28) received titanium screw implants. The screws were implanted into the femur of rabbits with surgically induced bone defects. Preoperatively, blood samples were collected and at 3, 7, 30, 60, 90, and 180 days postoperatively to assess liver and kidney function. On days after surgeries, seven rabbits from each group were anesthetized, and their liver, kidney, and brain tissues were collected for histological analysis. Results: Regarding liver and kidney function, the biochemical parameters showed minimal variations and remained within normal ranges throughout the study. In terms of tissue structure, the liver, kidney, and brain exhibited normal histological morphology in all experimental groups. Conclusion: HA-coated ZK60 screw implants, as well as uncoated ZK60 and titanium implants, demonstrated no significant effects on the structure and function of some organs such as the liver, kidneys, and brain.

Keywords

Toxicity to some organs, ZK60 implant, HA coating, Rabbit

Article Details

Author Biography

Tuan Anh Hoang, Bệnh viện Đại học Y Dược - Đại học Quốc gia Hà Nội

Bác sỹ khoa Hồi sức cấp cứu, Bệnh viện đại học Y dược - Đại học Quốc gia Hà Nội

References

1. Prakasam M, Locs J, Salma-Ancane K et al. Biodegradable materials and metallic implants-a review. J Funct Biomater. 2017; 8(4):44.
2. Jian SY, Lin CF, Tsai TL et al. In vivo degradation behavior of magnesium alloy for bone implants with improving biological activity, mechanical properties, and corrosion resistance. Int J Mol Sci. 2023; 24(2):1602.
3. Hiromoto S, Yamamoto A. High corrosion resistance of magnesium coated with hydroxyapatite directly synthesized in an aqueous solution. Electrochim Acta. 2009; 54:7085-7093.
4. Jian SY, Lin CF, Tsai TL et al. In vivo degradation behavior of magnesium alloy for bone implants with improving biological activity, mechanical properties, and corrosion resistance. Int J Mol Sci. 2023; 24(2):1602.
5. Charan J, Kantharia ND. How to calculate sample size in animal studies? J Pharmacol Pharmacother. 2013; 4(4):303-306.
6. Liu C, Wang J, Gao C and et al. Enhanced osteoinductivity and corrosion resistance of dopamine/gelatin/rhBMP-2-coated β-TCP/Mg-Zn orthopedic implants: An in vitro and in vivo study. PLoS One. 2020; 15(1):e0228247.
7. Song Y, Qin G, Du L and et al. In vitro and in vivo assessment of biocompatibility of AZ31 alloy as biliary stents: A preclinical approach. Arch Med Sci. 2020; 18(1):195-205.
8. Weikang Z, Jingfeng W, Jiang W and et al. A novel biodegradable Mg-1Zn-0.5Sn alloy: Mechanical properties, corrosion behavior, biocompatibility, and antibacterial activity. Journal of Magnesium and Alloys. 2020; 8(2):374-386.