RESEARCH ON THE ASSOCIATION BETWEEN THE FSHR rs6166 VARIANT AND SEMEN CHARACTERISTICS IN INFERTILE MEN IN VIETNAM
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Abstract
Objectives: To assess the association between single-nucleotide polymorphism (SNP) rs6166 in FSHR and semen parameters in patients with azoospermia and severe oligospermia of unknown etiology. Methods: A cross-sectional descriptive, controlled study was conducted on 410 individuals, including 210 patients with azoospermia, severe oligospermia and 200 controls. FSHR rs6166 was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The obtained data were analyzed using statistical methods. Results: The results showed that the FSHR rs6166 variant was not associated with the male infertility risk due to azoospermia and severe oligospermia. However, FSHR rs6166 was associated with decreased sperm motility, as the AA genotype in severe oligospermic patients was associated with decreased sperm motility compared to the GG genotype. Conclusion: The FSHR rs6166 variant is not likely associated with the male infertility risk due to azoospermia and severe oligospermia, but the AA genotype may be a risk factor for reduced sperm motility compared to the GG genotype.
Keywords
Semen characteristics, Male infertility, FSHR rs6166
Article Details
References
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