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Date Published: 10/12/2025
Abstract Views: 12
Views PDF: 2
DOI: 10.56535/jmpm.v50si4.1654
Issue
Vol. 50 No. si4 (2025): JOURNAL OF MILITARY PHARMACO-MEDICINE - SPECIAL ISSUE 12/2025
Section
Special issue celebrating the 75th anniversary of Military Hospital 103
How to Cite
Nguyen, T. L., Nguyen, M. H., Truong, D. T., Dang, T. T., & Pham, V. T. (2025). EVALUATION OF HISTOPATHOLOGICAL LESIONS OF GRAFT REJECTION ACCORDING TO THE 2022 BANFF CLASSIFICATION IN KIDNEY TRANSPLANT PATIENTS AT MILITARY HOSPITAL 103. Journal of Military Pharmaco-medicine, 50(si4), 306-314. https://doi.org/10.56535/jmpm.v50si4.1654

EVALUATION OF HISTOPATHOLOGICAL LESIONS OF GRAFT REJECTION ACCORDING TO THE 2022 BANFF CLASSIFICATION IN KIDNEY TRANSPLANT PATIENTS AT MILITARY HOSPITAL 103

Thuy Linh Nguyen1, , Mai Hanh Nguyen1, Dinh Tien Truong1, Thai Tra Dang1, Van Thinh Pham1
1 Bộ môn - Khoa Giải phẫu bệnh lý, Pháp y, Bệnh viện Quân y 103, Học viện Quân y

Main Article Content

Abstract

Objectives: To evaluate the histopathological lesions of graft rejection in  kidney  transplant patients  according  to the  2022 Banff classification. Methods: A retrospective study was conducted on 99 patients who underwent renal allograft biopsy and were diagnosed with graft rejection at Military Hospital 103 from January 2021 to July 2025. Results: Patients receiving kidney transplants were mainly male (70.7%), received kidney transplants from living donors (97.98%), and were not genetically related (80.81%). Patients had a positive DSA rate of 26.27% and all negative crossmatches. Glomerulitis, intimal arteritis, and peritubular capillaritis in antibody-mediated rejection (AMR) were all mild. Tubulitis and interstitial inflammation, shown in T cell-mediated rejection (TCMR), were mainly mild. Categories 2 and 4 accounted for similar proportions (33.33 and 36.36%). In category 2, chronic AMR accounted for more than half (54.55%), and microvascular inflammation/injury (MVI) - a new subtype in the 2022 Banff classification, accounted for 9.09%. Conclusion: Based on the assessment of histopathologicallesion scores of renal allograft biopsy according to the 2022 Banff classification, the rejection groups and subgroups were divided, assisting in the monitoring and treatment of patients.

Keywords

Banff classification, Banff lesion score, Renal allograft

Article Details

References

1. Naesens M, Roufosse C, Haas M, et al. The Banff 2022 kidney meeting report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics. American Journal of Transplantation. 2024; 24(3):338-349.
2. Katsuma A, Yamakawa T, Nakada Y, et al. Histopathological findings in transplanted kidneys. Renal Replacement Therapy. 2017/02/16 2017; 3(1):6.
3. Lê Anh Tuấn, Nguyễn Trường Giang, Hoàng Mạnh An. Nghiên cứu đặc điểm mạch máu của thận ghép, kỹ thuật và kết quả khâu nối mạch máu trong ghép thận tại Bệnh viện Quân y 103. TC Y học TP Hồ Chí Minh. 2016; 20(4):86-90.
4. Hoàng Mạnh An, Đỗ Tất Cường, Bùi Văn Mạnh. Nhiễm trùng thường gặp sau ghép thận: Kinh nghiệm tại Bệnh viện Quân y 103. TC Y Học TP HCM. 2016; 20(4):40-44.
5. John EE, Mehta S, Sohal PM, Sandhu JS. Predictors of short-term outcomes in living donor renal allograft recipients: A prospective study from a tertiary care center in North India. Cureus. Aug 2022; 14(8):e28335.
6. Bashir S, Hussain M, Ali Khan A, et al. Renal transplant pathology: Demographic features and histopathological analysis of the causes of graft dysfunction. Int J Nephrol. 2020; 2020:7289701.
7. Filippone EJ, McCue PA, Farber JL. Transplant glomerulopathy. Modern Pathology. 2018/02/01 2018; 31(2):235-252.
8. Torres IB, Salcedo M, Moreso F, et al. Comparing transplant glomerulopathy in the absence of C4d deposition and donor-specific antibodies to chronic antibody-mediated rejection. Clin Transplant. Oct 2014; 28(10):1148-1154.