MỘT SỐ ĐẶC ĐIỂM BIẾN THIÊN NỒNG ĐỘ CỦA THUỐC TACROLIMUS Ở BỆNH NHÂN SAU GHÉP THẬN

Abstract

Objectives: To investigate Tacrolimus's (TAC) concentration and intra-patient variability of Tacrolimus concentrations and analyze its relationship with some clinical and subclinical characteristics in patients after kidney transplantation from the 7^th to the 12^th month. Methods: A retrospective, prospective, cross-sectional descriptive study was conducted on 108 patients who were evaluated for the coefficient of variation of TAC concentration based on the quantification of TAC trough concentrations at the 7^th to the 12^th month post-kidney transplantation. The distribution of drug concentration variation was based on the quartile principle. Results: The median IPV of the study group from  7^th to 12^th month was 19.0%, with a minimum of 6.84% and a maximum of 57.84%. The proportion of patients with high IPV was 13.9%. IPV was not significantly associated with age, sex, eGFR, MMF dose, hemoglobin concentration, and post-transplant proteinuria, with p > 0.05. IPV was associated considerably with TAC trough concentrations at months 8, 9, and 10; p < 0.05. IPV was significantly related to TAC trough concentrations at months 8, 9, and 10; p < 0.05. Conclusion: The IPV of the study group during the 6 months (7^th to 12^th) fluctuated significantly and was significantly related to trough concentrations at months 8, 9, and 10.