CLINICAL AND PARACLINICAL CHARACTERISTICS OF SOLID PSEUDOPAPILLARY NEOPLASMS OF THE PANCREATIC BODY AND TAIL AT VIET DUC UNIVERSITY HOSPITAL

Viet Khai Ninh1, Minh Toan Nguyen2, Chi Thanh Ho2,
1 Bệnh viện Hữu nghị Việt Đức
2 Bệnh viện Quân y 103, Học viện Quân y

Main Article Content

Abstract

Objectives: To describe clinical and paraclinical characteristics of solid pseudopapillary neoplasms (SPNs) located in the body and tail of the pancreas. Methods: A retrospective, descriptive study was conducted on 39 patients who were diagnosed with SPNs in the pancreatic body or tail and underwent surgery at Viet Duc University Hospital from December 1, 2014 to November 30, 2019. Results: The mean age was 27.3 ± 11.15 years, 94.9% were females, abdominal pain symptom was 72.8%, and abdominal examination showed no symptoms in 89.7%. The rate of CA 19-9 > 37 U/mL in blood was 17.1%. Abdominal ultrasound showed that tumors had a mixed solid-cystic structure in 51.4% and clear boundaries in 81.1%. Abdominal CT scan showed a mean tumor size of 59.5 ± 28.2mm, a rate of tumors with low contrast enhancement of 78.4%, non-vascular invasion of 97.3% and capsule of 29.7%. Histopathology: Solid was 28.2%, cystic was 12.8% and mixed was 59%. Conclusion: The age of onset is young, often in women, abdominal pain is the main symptom, and the symptoms are atypical on physical examination. A mixed solid-cystic with clear boundaries on Ultrasound, and a low-contrast image without vascular invasion on CT scan are important factors in diagnosis and treatment.

Article Details

References

1. Yu P, Hu Z, Wang X, et al. Solid pseudopapillary tumor of the pancreas: A review of 553 cases in Chinese literature. World Journal of Gastroenterology: WJG. 2010; 16(10):1209.
2. Allam M, Salinas H, Machairas N, et al. Solid pseudopapillary neoplasms of the pancreas: A single-center experience and review of the literature. J Gastrointest Cancer. 2022; 53(2):460-465.
3. Zhao M, Wang J, Lai J, et al. Solid pseudopapillary neoplasms of the pancreas (SPNs): Diagnostic accuracy of CT and CT imaging features. World J Surg Oncol. 2024; 22(1):225.
4. Pawlak KM, Tehami N, Maher B, et al. Role of endoscopic ultrasound in the characterization of solid pseudopapillary neoplasm of the pancreas. World J Gastrointest Endosc. 2023; 15(4):273-284.
5. Nguyễn Minh Trọng, Nguyễn Kiều Hưng, Phạm Bá Đức và CS. Kết quả điều trị phẫu thuật u đặc giả nhú ở thân đuôi tụy tại Bệnh viện Hữu nghị Việt Đức. Tạp chí Y học Việt Nam. 2021; 507(1):236-240.
6. Phạm Duy Hiền, Vũ Mạnh Hoàn, Nguyễn Công Sơn và CS. Kết quả phẫu thuật điều trị u đặc giả nhú của tụy ở trẻ em tại Bệnh viện Nhi Trung ương: Nhân 15 trường hợp. Tạp chí Y học Việt Nam. 2023; 529(1):5-9.
7. Wang X, Zhu D, Bao W, et al. Prognostic enigma of pancreatic solid pseudopapillary neoplasm: A single-center experience of 63 patients. Front Surg. 2021; 8:771587.
8. Aydiner F, Erinanç H, Savaş B, et al. Solid pseudopapillary tumor of the pancreas: Emphasis on differential diagnosis from aggressive tumors of the pancreas. Turk J Gastroenterol. 2006; 17(3):219-222.
9. Tang S, Huang LP, Wang Y, et al. Solid pseudopapillary tumors of the pancreas: Contrast-enhanced sonographic features. J Ultrasound Med. 2012; 31(2):257-263.
10. De Robertis R, Marchegiani G, Catania M, et al. Solid pseudopapillary neoplasms of the pancreas: Clinicopathologic and radiologic features according to size. AJR Am J Roentgenol. 2019; 213(5):1073-1080.