PROGNOSTIC SIGNIFICANCE OF p-STAT3 AND p-AMPKα IMMUNOHISTOCHEMICAL EXPRESSION IN GASTRIC CARCINOMA PATIENTS FOLLOWING CURATIVE GASTRECTOMY
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Abstract
Objectives: To evaluate the prognostic significance of p-STAT3 expression and its association with p-AMPKα expression in gastric carcinoma tissues. Methods: A descriptive longitudinal study was conducted on 68 patients with gastric carcinoma who underwent curative gastrectomy. The expressions of p-STAT3 and p-AMPKα in tumor tissues were assessed using immunohistochemistry. Their associations with biochemical parameters, tumor markers, and postoperative mortality risk were analyzed using appropriate statistical tests and a multivariate Cox regression model. Results: Positive p-STAT3 expression was identified as an adverse prognostic factor, significantly associated with increased postoperative mortality risk (HR = 53.973; p = 0.018). p-AMPKα showed no association with p-STAT3 and did not demonstrate a clear prognostic role for postoperative mortality risk (HR = 0.185; p = 0.137). No significant differences were observed in serum levels of CEA, CA19-9, and CA72-4 across the groups. Conclusion: In patients with gastric carcinoma undergoing curative gastrectomy, positive p-STAT3 expression is a undesirable prognostic factor associated with higher postoperative mortality risk, whereas the prognostic value of p-AMPKα remains inconclusive.
Keywords
Gastric carcinoma, p-STAT3, p-AMPKα, Prognosis, Curative surgery
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References
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