MỐI LIÊN QUAN GIỮA NỒNG ĐỘ OSTEOPROTEGERIN HUYẾT TƯƠNG VỚI MỘT SỐ ĐẶC ĐIỂM TỔN THƯƠNG Ở BỆNH NHÂN NHỒI MÁU CƠ TIM CẤP CÓ ST CHÊNH LÊN

Abstract

Objectives: To evaluate the association between serum Osteoprotegerin (OPG) levels and left ventricular function in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). Methods: A prospective, cross-sectional descriptive study was conducted on 82 patients diagnosed with STEMI at the Cardiovascular Center, Military Hospital 103 in 2024. Serum OPG levels, left ventricular ejection fraction (LVEF), and left ventricular global longitudinal strain (LVGLS) were measured before and within 7 days after the intervention. Results: The mean age was 65.96 ± 11.14 years, with 82.9% being male. Post-PCI, left ventricular function significantly improved, with LVEF increasing from 45.44 ± 10.57% to 49.31 ± 10.49% (p < 0.001) and LVGLS improving from -11.90 ± 3.25% to -13.12 ± 3.41 (p < 0.001). In the late-presenting patient group (> 12 hours, n = 33), admission OPG levels demonstrated a significant negative correlation with admission LVEF (r = -0.439, p = 0.011), admission LVGLS (r = -0.451, p = 0.008), and post-PCI LVGLS (r = -0.465, p = 0.006). Conclusion: OPG may serve as a valuable biomarker for the early identification of late-presenting patients at high risk of severe myocardial injury.