RELATIONSHIP BETWEEN PLASMA URIC ACID CONCENTRATION AND SOME CLINICAL AND PARACLINICAL CHARACTERISTICS IN PREGNANT WOMEN

Le Thanh Thu Nguyen1, Lê Đình Tuân2, , Tien Son Nguyen2, Minh Nui Nguyen2, Thi Hong Van Le3, Nguyen Hung Dao3, Hien Trinh Vu4, Van Thuan Nguyen5, Thi Thuy Dieu Hoang6, Huy Hoang Duong6, Trung Kien Nguyen6, Minh Tien Bui6, Latsavong Mixay7, Thi Lieu Pham8
1 Ban Giáo vụ, Bệnh viện Quân y 103, Học viện Quân y
2 Bộ môn Khớp và Nội tiết, Bệnh viện Quân y 103, Học viện Quân y
3 Bộ môn Phụ Sản, Bệnh viện Quân y 103, Học viện Quân y
4 Bệnh viện Nội tiết Trung ương
5 Khoa Cán bộ Cao cấp, Bệnh viện Quân y 103, Học viện Quân y
6 Trường Đại học Y Dược Thái Bình
7 Bệnh viện Trung ương Quân đội 103 Lào
8 Ban Khoa học Quân sự, Bệnh viện Quân y 103, Học viện Quân y

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Abstract

Objectives: To investigate the plasma uric acid concentration and its relationship with clinical and paraclinical characteristics in pregnant women. Methods: A prospective, cross-sectional descriptive study was conducted on 80 pregnant women at Military Hospital 103. Results: The mean uric acid concentration was 262.91 ± 45.49 µmol/L (126 - 380 µmol/L). The percentage of pregnant women with increased uric acid concentration was 3.8%. The mean uric acid concentration in the group with fetal weight smaller than gestational age was lower than that in the group of fetuses with normal weight (239.05 ± 51.41 µmol/L vs. 268.42 ± 42.56 µmol/L; p < 0.05); The mean uric acid concentration was significantly higher in the group with increased blood glucose concentration after 1 hour of the glucose tolerance test (307.52 ± 41.02 µmol/L vs. 259.94 ± 44.44 µmol/L, p < 0.05). Uric acid concentration was inversely correlated with serum potassium concentration (r = -0.26; p < 0.05). There was no association between uric acid concentration, maternal age, blood pressure, weight, and liver enzymes in pregnant women. Conclusion: The mean uric acid concentration in pregnant women was 262.91 ± 45.49 µmol/L, plasma uric acid concentration was related to potassium concentration, fetal weight for age, and blood glucose levels after 1 hour of the glucose tolerance test. 

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References

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