Tỷ lệ vô tinh, thiểu tinh nhẹ thiểu tinh nặng và nồng độ hormone sinh sản ở bệnh nhân vô sinh có vi mất đoạn AZF tại Bệnh viện Nam học Hiếm muộn Hà Nội

Abstract

Objectives: To investigate the azoospermia, oligozoospermia, severe oligozoospermia rate, and reproductive hormonal concentration of azoospermia patients with AZF microdeletion in Fertility and Andrology Hospital of Hanoi. Subjects and methods: A retrospective, descriptive, and cross-sectional study on 166 Vietnamese men with AZF microdeletion in patients with oligozoospermia or azoospermia at in Andrology and Fertility Hospital of Hanoi from December 2016 to June 2021. Results: AZFc microdeletion accounts for the majority (51.81%) of AZF microdeletions. Combined AZF microdeletion accounts for 42.77%. The rate of AZFa deletion was 1.81%. 3/3 cases AZFa microdeletion were azoospermia. Deletion of AZFc resulted in 27% azoospermia, 58% severe oligospermia, and 13% oligospermia. 100% AZFa microdeletion is azoospermia. AZFbc microdeletion has an azoospermia rate of 71.42%, and AZFbcd microdeletion has an azoospermia rate of 52%. AZFa deletion had a high FSH concentration (36.67 ± 12.70 IU/l). Conclusion: The rate of AZFc microdeletion was the highest at 51.81%. Isolated and combined AZFa microdeletions impact spermatogenesis more severely than other types of deletions.