Kết quả áp dụng quy trình xét nghiệm di truyền trước làm tổ bệnh Hemophilia A

Abstract

Objectives: To evaluate the results of applying the pre-implantation genetic testing in families carrying the Hemophilia A gene. Subjects and methods: Using linkage genetic analysis technique for pre-implantation genetic testing of 16 families with Hemophilia A gene who were performed embryogenation and embryo biopsy at the Andrology and Fertility Hospital of Hanoi, from September 2018 to December 2021. Results: 117 blastocysts of 16 couples classified according to morphology included 85 good embryos (72.65%), 30 fair embryos (25.64%), 2 poor embryos (1.71%). Among 115 embryos of a good and fair type which were performed a biopsy and genetic diagnosis, there were 70 normal embryos (60.87%), 26 carried embryos (22.61%), and 19 disease affected embryos (16.52%). Conclusion: Hemophilia A gene carrier status was successfully diagnosed in 115 embryos of 16 couples participating in the study.