KHẢO SÁT MỐI LIÊN QUAN GIỮA KHÁNG INSULIN VỚI MỘT SỐ ĐẶC ĐIỂM Ở NGƯỜI BỆNH ĐÁI THÁO ĐƯỜNG MỚI KHỞI PHÁT SAU GHÉP THẬN

Abstract

Objectives: To investigate insulin resistance status and its association with some characteristics in patients with new-onset diabetes after kidney transplantation (NODAT). Methods: A cross-sectional descriptive study was conducted on 81 patients with untreated NODAT and 53 age- and sex-matched healthy controls at Military Hospital 103 from October 2021 to December 2023. Clinical and laboratory characteristics were collected, and insulin resistance indices were calculated using the HOMA2 model, including insulin resistance (HOMA2-IR), insulin sensitivity (HOMA2-S), and β-cell function (HOMA2-B). Results: The median HOMA2-IR in the NODAT group was 0.95, which was significantly higher than that of the control group (0.7); p < 0.001. In contrast, both HOMA2-S and HOMA2-B were markedly reduced in the NODAT group compared to the control group (p < 0.001). Among NODAT patients, the prevalence of elevated HOMA2-IR, decreased HOMA2-S, and impaired HOMA2-B was 18.5%, 19.8%, and 27.2%, respectively. Patients with increased HOMA2-IR or reduced HOMA2-S exhibited significantly greater waist circumference, higher mean BMI, with those without these abnormalities, and the rate of increased HOMA2-IR was significant with OR 6,08 and 7,0, respectively (p < 0.05). Conclusion: Insulin resistance in NODAT patients is associated with increased waist circumference and higher BMI,