GIÁ TRỊ TIÊN LƯỢNG CỦA CHỈ SỐ DINH DƯỠNG TIÊN LƯỢNG Ở BỆNH NHÂN U LYMPHO TẾ BÀO B LỚN LAN TOẢ

Abstract

Objectives: To determine the prognostic significance of the prognostic nutritional index (PNI) in individuals diagnosed with diffuse large B-cell lymphoma (DLBCL). Methods: A combined retrospective and prospective, cohort study was conducted on 112 patients with DLBCL diagnosed and treated at Military Hospital 103 between January 2019 and June 2025. Results: Compared to the PNI < 43.8 group, the PNI ≥ 43.8 group had a higher proportion of patients aged ≤ 60 years (75.9% vs. 57.4%), more cases were at stage I - II (72.2% vs. 51.7%), and a greater percentage with R-IPI scores of 0 - 2 (74.1% vs. 46.6%). The rate of B-symptoms was significantly lower (18.5% vs. 37.9%) (p < 0.05). The higher PNI group (≥ 43.8) also achieved greater rates of disease control (90.7% vs. 74.1%) and complete response (79.6% vs. 56.9%). Compared with the lower PNI group (< 43.8), they experienced a 66.9% reduction in the risk of progression and a 69.7% reduction in the risk of death. At the 3-year, PFS and OS rates in the PNI ≥ 43.8 group were 57.4% and 75.9%, respectively, compared with 37.9% and 60.3% in the PNI < 43.8 group (p < 0.0001). Conclusion: PNI correlates with treatment responseand may serve as an independent prognostic factor for both PFS and OS in DLBCL patients.