NGHIÊN CỨU MỘT SỐ CHỈ SỐ CẬN LÂM SÀNG, TỔN THƯƠNG MÔ BỆNH HỌC GAN Ở CÔNG NHÂN TIẾP XÚC NGHỀ NGHIỆP VỚI TRINITROTOLUEN

Abstract

Objectives: To evaluate some paraclinical indices and histopathological liver damagein workers with occupational exposure to Trinitrotoluen (TNT). Methods: A retrospective, prospective, and cross-sectional descriptive study was conducted on 177 patients diagnosed with chronic hepatitis due to occupational exposure to TNT and were clinically examined, had blood counts, blood biochemistry tests, and liver biopsy; and assess histopathological liver damage and its relationship with paraclinical characteristics. Results: 2.8% accounted for anemia; 12.4% accounted for microcytic red blood cells; liver fibrosis stage included F0: 55.9%, F1: 36.2%, F2: 7.9%; liver fibrosis (F1 + F2): 44.1%; significant fibrosis (F2): 7.9%. Increased GGT in group F1 + F2 was higher than in group F0, p < 0.05; increased GGT group F2 in was higher than that in group F0 + F1, p < 0.05; group F1+ F2 had a higher rate of increased bilirubin than F0, p < 0.05. Conclusion: Histopathological liver lesions were mainly chronic hepatitis without liver fibrosis F0 (55.9%), stage fibrosis F1 (36.2%), and F2 (7.9%). There was a correlation between fibrosis stages and total bilirubin index, blood GGT activity.