ANTITUSSIVE AND EXPECTORANT EFFECTS OF AN EXTRACT OF OPHIOPOGON JAPONICUS IN MICE
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Abstract
Objectives: To assess the antitussive and expectorant therapeutic effects of Ophiopogon japonicus extract in Swiss albino mice. Methods: The study was conducted on Swiss mice (n = 8) divided into 4 groups: A control group, a codeine phosphate-treated group (30 mg/kg), and 2 groups receiving Ophiopogon japonicus at doses of 2.4 g/kg or 7.2 g/kg administered orally for three consecutive days. Cough was induced using ammonia; the latency to the first cough and the frequency of coughs over a five-minute period were recorded. Phenol red was injected and its tracheal excretion measured to evaluate the expectorant effect. Results: Ophiopogon japonicus extract reduced the cough frequency by 46% (at 2.4 g/kg) and 39 % (7.2 g/kg) and increased phenol red secretion by 1.4 to1.6 times. These effects did not demonstrate a clear dose-dependent response. Conclusion: Ophiopogon japonicus extract exhibits potential antitussive and expectorant activities in Swiss mice.
Keywords
Ophiopogonis japonicus extract, Antitussive, Expectorant, Swiss albino mice
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References
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