NGHIÊN CỨU ĐẶC ĐIỂM NỒNG ĐỘ KẼM Ở BỆNH NHÂN BỆNH THẬN MẠN TÍNH GIAI ĐOẠN CUỐI ĐIỀU TRỊ TẠI BỆNH VIỆN QUÂN Y 103

Abstract

Objectives: To investigate and determine the changes in serum Zinc (Zn) levels in patients with end-stage renal disease (ESRD). Methods: A cross-sectional descriptive study comparing 3 groups: The hemodialysis (HD) group comprising 100 ESRD patients undergoing hemodialysis; the not-dialysis group comprising 20 ESRD patients indicated for dialysis but not yet initiated; and a control group comprising 50 healthy individuals. Results: The prevalence of Zn deficiency was 43.0% in the HD group and 45.0% in the pre-dialysis group, significantly higher than that in the control group (6.0%), with p = 0.000. Zinc levels showed a decreasing trend from the control group at 78.5 µg/dL (65.2 - 97.7) to the pre-dialysis group at 51.6 µg/dL (34.8 - 65.7), and lowest in the HD group at 50.1 µg/dL (35.1 - 69.6); this difference was statistically significant (p = 0.000). Zn levels tended to decrease with age; however, there were no significant differences in Zn levels by gender, dialysis duration (< 12 months vs. ≥ 12 months), or BMI (< 18.5 vs. ≥ 18.5). Conclusion: Zn deficiency occurred in 43.0% ESRD patients with hemodialysis and 45.0% ESRD without hemodialysis, significantly higher than in the control group (6.0%). Serum Zn of ESRD patients is lower than that of healthy individuals. Serum Zn was associated with increased age.