KẾT QUẢ HÓA XẠ TRỊ ĐỒNG THỜI UNG THƯ VÒM MŨI HỌNG GIAI ĐOẠN II - IVA TẠI BỆNH VIỆN ĐA KHOA BẮC NINH SỐ 2

Abstract

Objectives: To describe the clinical and paraclinical characteristics and evaluate the treatment outcomes of stage II - IVA nasopharyngeal carcinoma (NPC) treated with concurrent chemoradiotherapy at Bac Ninh General Hospital No.2. Methods: A retrospective, descriptive study was conducted on 40 patients with confirmed stage II - IVA NPC who received concurrent chemoradiotherapy at Bac Ninh General Hospital No.2 over the period from January 2018 to December 2022. Results: The mean age at diagnosis was 52.85 ± 8.75 years, with a male-to-female ratio of 1.6:1. All patients received a full radiation dose of 70Gy. Achieving a complete response was observed in 85% of patients, while 15% exhibited a partial response. At 3 and 5 years, overall survival rates reached 92.5% and 83.4%, respectively. Similarly, disease-free survival was recorded at 86.5% after 3 years and 83.3% after 5 years. Recurrence and distant metastasis occurred in 15% of patients. Common late toxicities included grade 1 - 2 xerostomia (90%), grade 1 - 2 dental complications (67.5%), and grade 1 chronic rhinosinusitis (45%). Conclusion: Concurrent chemoradiotherapy is a highly effective treatment for stage II - IVA NPC. Common late toxicities, primarily grade 1 - 2, include xerostomia, dental complications, and rhinosinusitis.