NGHIÊN CỨU BIẾN ĐỔI MỘT SỐ CHỈ SỐ CẬN LÂM SÀNG Ở BỆNH NHÂN TÂM THẦN PHÂN LIỆT ĐIỀU TRỊ BẰNG KÍCH THÍCH ĐIỆN TRỰC TIẾP XUYÊN SỌ

Abstract

Objectives: To evaluate changes in plasma dopamine, electroencephalography (EEG), and PANSS scores in schizophrenia patients treated with transcranial direct current stimulation (tDCS). Methods: A prospective, controlled clinical trial was conducted on 140 schizophrenia patients who were divided into two groups, including 70 patients for each group: The intervention group (tDCS + olanzapine) compared to the control group (olanzapine only). Patients were diagnosed according to DSM-5 criteria and treated at the Department of Psychiatry, Military Hospital 103, from June 2024 to March 2025. Plasma dopamine levels, EEG, and PANSS scores were measured before (T0) and after intervention (T1, days 21 - 24). Results: The tDCS group showed a 52% dopamine reduction (78.7 → 37.8 ng/mL, p = 0.001), increased alpha waves (54.3% → 70.7%), decreased slow waves (30.6% → 13.6%), increased positive photic response (69.2% → 84.8%, p < 0.05), and reduced PANSS scores (positive: 18%, negative: 15%, general: 17%, p < 0.05), outperforming the control group (dopamine reduced 30%, PANSS reduced 5 - 10%). Dopamine was weakly correlated with positive PANSS (r = 0.245, p = 0.004).Conclusion: tDCS combined with olanzapine significantly improves plasma dopamine, EEG, and PANSS scores in schizophrenia patients, particularly who have negative symptoms.